Two cases of acute myelitis with idiopathic hypereosinophilic syndrome.

Rie Tohge, Yoko Warabi, Makio Takahashi, Masahiro Nagao

Open access · bronzeAbstract readCase Reports

In one paragraph

Article in BMJ case reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.5field-weighted citation impact, top 32% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Rie TohgeDepartment of Neurology, Tokyo Metropolitan, Neurological Hospital, Fuchu, Tokyo, Japan Department of Neurology, Osaka Red Cross Hospital, Osaka, Japan.

Yoko WarabiDepartment of Neurology, Tokyo Metropolitan, Neurological Hospital, Fuchu, Tokyo, Japan.

Makio TakahashiDepartment of Neurology, Osaka Red Cross Hospital, Osaka, Japan.

Masahiro NagaoDepartment of Neurology, Tokyo Metropolitan, Neurological Hospital, Fuchu, Tokyo, Japan.

Tokyo Metropolitan Neurological Hospital · JPOsaka Red Cross Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Idiopathic hypereosinophilic syndrome (IHES) is characterised by persistent eosinophilia and organ damage after ruling out other causes. IHES is clinically and pathologically heterogeneous, and several disease mechanisms have been described. Although neurological involvement with IHES is extremely rare, we report the first cases of acute myelitis with IHES, which are confirmed using MRI, fulfil the diagnostic criteria of IHES and pathologically reveal eosinophilic tissue infiltration in the liver and skin. Patient 1 had longitudinally extensive transverse myelitis, which developed in the absence of steroid therapy. Patient 2 developed acute myelitis with two short lesions during a 3 mg/day corticosteroid treatment. Both cases had eosinophilia (>1500/mm(3)) at the onset of myelitis. These findings suggest that earlier treatment and a sufficient dose of corticosteroids may prevent the lesional expansion in acute myelitis. Steroid therapy should be initiated early before organ involvement, because permanent neuronal damage with a larger lesion becomes more critical.

Indexed as

AdultAgedAnti-Inflammatory AgentsHumansHypereosinophilic SyndromeMagnetic Resonance ImagingMaleMethylprednisoloneMyelitis, TransverseAnti-Inflammatory AgentsMethylprednisolone

Identifiers

PMID24849647

DOI10.1136/bcr-2014-204326

PMCPMC4039971

OpenAlexW2030624638

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.