ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Involvement of BDNF signaling transmission from basolateral amygdala to infralimbic prefrontal cortex in conditioned taste aversion extinction.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 46 citations in OpenAlex.
- Molecular architects of memory: BDNF/TrkB signaling and trafficking in neuronal plasticity and memory.Molecular psychiatry · 2026Review
- From gastric to neuroprotection: pantoprazole mitigates epilepsy via TrkB/BDNF and KCC2 modulation.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Altered fear engram encoding underlying conditioned versus unconditioned stimulus-initiated memory updating.Science advances · 2023Article
- Update on neurobiological mechanisms of fear: illuminating the direction of mechanism exploration and treatment development of trauma and fear-related disorders.Frontiers in behavioral neuroscience · 2023Review
- Distinct Progressions of Neuronal Activity Changes Underlie the Formation and Consolidation of a Gustatory Associative Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Ayahuasca blocks the reinstatement of methylphenidate-induced conditioned place preference in mice: behavioral and brain Fos expression evaluations.Psychopharmacology · 2020Article
- The basolateral amygdala-medial prefrontal cortex circuitry regulates behavioral flexibility during appetitive reversal learning.Behavioral neuroscience · 2020Article
- Sign-tracking behavior is difficult to extinguish and resistant to multiple cognitive enhancers.Neurobiology of learning and memory · 2019Article
- Conditioned taste aversion memory extinction temporally induces insular cortical BDNF release and inhibits neuronal apoptosis.Neuropsychiatric disease and treatment · 2019Article
- Stroke Induces a BDNF-Dependent Improvement in Cognitive Flexibility in Aged Mice.Neural plasticity · 2019Article
- On the Involvement of BDNF Signaling in Memory Reconsolidation.Frontiers in cellular neuroscience · 2019Review
- Effects of lesions in different nuclei of the amygdala on conditioned taste aversion.Experimental brain research · 2017Article
- Pre-synaptic TrkB in basolateral amygdala neurons mediates BDNF signaling transmission in memory extinction.Cell death & disease · 2017Article
- Cognitive flexibility impairment and reduced frontal cortex BDNF expression in the ouabain model of mania.Neuroscience · 2017Article
- Regulation and function of MeCP2 Ser421 phosphorylation in U50488-induced conditioned place aversion in mice.Psychopharmacology · 2017Article
- The Insula and Taste Learning.Frontiers in molecular neuroscience · 2017Review
- Choice Behavior Guided by Learned, But Not Innate, Taste Aversion Recruits the Orbitofrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Acute immobilization stress following contextual fear conditioning reduces fear memory: timing is essential.Behavioral and brain functions : BBF · 2016Article
- Intensity of anxiety is modified via complex integrative stress circuitries.Psychoneuroendocrinology · 2016Article
- Blocking Infralimbic Basic Fibroblast Growth Factor (bFGF or FGF2) Facilitates Extinction of Drug Seeking After Cocaine Self-Administration.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
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7 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase receptor B (TrkB), play a critical role in memory extinction. However, the detailed role of BDNF in memory extinction on the basis of neural circuit has not been fully understood. Here, we aim to investigate the role of BDNF signaling circuit in mediating conditioned taste aversion (CTA) memory extinction of the rats. We found region-specific changes in BDNF gene expression during CTA extinction. CTA extinction led to increased BDNF gene expression in the basolateral amygdala (BLA) and infralimbic prefrontal cortex (IL) but not in the central amygdaloid nucleus (CeA) and hippocampus (HIP). Moreover, blocking BDNF signaling or exogenous microinjection of BDNF into the BLA or IL could disrupt or enhance CTA extinction, which suggested that BDNF signaling in the BLA and IL is necessary and sufficient for CTA extinction. Interestingly, we found that microinjection of BDNF-neutralizing antibody into the BLA could abolish the extinction training-induced BDNF mRNA level increase in the IL, but not vice versa, demonstrating that BDNF signaling is transmitted from the BLA to IL during extinction. Finally, the accelerated extinction learning by infusion of exogenous BDNF in the BLA could also be blocked by IL infusion of BDNF-neutralizing antibody rather than vice versa, indicating that the IL, but not BLA, is the primary action site of BDNF in CTA extinction. Together, these data suggest that BLA-IL circuit regulates CTA memory extinction by identifying BDNF as a key regulator.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.