ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed.
- GATA4-Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age-Related Audio-Vestibular Dysfunction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Investigating Cerebello-Cortical Networks With EEG: Advances and Future Challenges.Cerebellum (London, England) · 2026Review
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- Synaptic weight dynamics underlying memory consolidation: Implications for learning rules, circuit organization, and circuit function.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Restoring cerebellar-dependent learning.eLife · 2024Article
- Interactions between circuit architecture and plasticity in a closed-loop cerebellar system.eLife · 2024Article
- Purkinje cell models: past, present and future.Frontiers in computational neuroscience · 2024Review
- Expression of a Form of Cerebellar Motor Memory Requires Learned Alterations to the Activity of Inhibitory Molecular Layer Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Synaptic basis of a sub-second representation of time in a neural circuit model.Nature communications · 2022Article
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- Protective effect of anakinra on audiovestibular function in a murine model of endolymphatic hydrops.Frontiers in cellular neuroscience · 2022Article
- Intrinsic Plasticity of Cerebellar Purkinje Cells Contributes to Motor Memory Consolidation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- A Neuroanatomically Grounded Optimal Control Model of the Compensatory Eye Movement System in Mice.Frontiers in systems neuroscience · 2020Article
- Plasticity leading to cerebellum-dependent learning: two different regions, two different types.Pflugers Archiv : European journal of physiology · 2019Review
- Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation.PLoS computational biology · 2019Article
- The Emerging Concept of Intrinsic Plasticity: Activity-dependent Modulation of Intrinsic Excitability in Cerebellar Purkinje Cells and Motor Learning.Experimental neurobiology · 2018Review
- Modeling the Encoding of Saccade Kinematic Metrics in the Purkinje Cell Layer of the Cerebellar Vermis.Frontiers in computational neuroscience · 2018Article
- A Metric for Evaluating Neural Input Representation in Supervised Learning Networks.Frontiers in neuroscience · 2018Article
- Spatiotemporal network coding of physiological mossy fiber inputs by the cerebellar granular layer.PLoS computational biology · 2017Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Mechanisms of cerebellar motor learning are still poorly understood. The standard Marr-Albus-Ito theory posits that learning involves plasticity at the parallel fiber to Purkinje cell synapses under control of the climbing fiber input, which provides an error signal as in classical supervised learning paradigms. However, a growing body of evidence challenges this theory, in that additional sites of plasticity appear to contribute to motor adaptation. Here, we consider phase-reversal training of the vestibulo-ocular reflex (VOR), a simple form of motor learning for which a large body of experimental data is available in wild-type and mutant mice, in which the excitability of granule cells or inhibition of Purkinje cells was affected in a cell-specific fashion. We present novel electrophysiological recordings of Purkinje cell activity measured in naive wild-type mice subjected to this VOR adaptation task. We then introduce a minimal model that consists of learning at the parallel fibers to Purkinje cells with the help of the climbing fibers. Although the minimal model reproduces the behavior of the wild-type animals and is analytically tractable, it fails at reproducing the behavior of mutant mice and the electrophysiology data. Therefore, we build a detailed model involving plasticity at the parallel fibers to Purkinje cells' synapse guided by climbing fibers, feedforward inhibition of Purkinje cells, and plasticity at the mossy fiber to vestibular nuclei neuron synapse. The detailed model reproduces both the behavioral and electrophysiological data of both the wild-type and mutant mice and allows for experimentally testable predictions.
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