ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
The molecular and cellular basis of taste coding in the legs of Drosophila.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.
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101 citing papers in PubMed.
- Insulin receptor signaling in gustatory cells suppresses sugar taste sensitivity and feeding iniScience · 2026Article
- Expanding the sensory horizon: chemosensory receptors beyond traditional olfactory and taste organs in insects.Science China. Life sciences · 2026Review
- Gustatory avoidance of fatty acids byProceedings of the National Academy of Sciences of the United States of America · 2026Article
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- TRP Channels from Sensory Coding to Physiology.Metabolites · 2025Review
- Identification and Functional Characterization of the Leg-Enriched Chemosensory Protein PxylCSP9 inBiology · 2025Article
- Article
- Gustatory receptors interact with the serotonin pathway to regulate silkmoth stereotyped courtship behavior.BMC biology · 2025Article
- How Sugar Quality and Concentration Influence Oviposition Preference in Drosophila Melanogaster.Journal of chemical ecology · 2025Article
- Molecular Characterization and Functional Analysis of Odorant-Binding Proteins inInternational journal of molecular sciences · 2025Article
- Behavioral Assays for Optogenetic Manipulation of Neural Circuits in Drosophila melanogaster.Journal of visualized experiments : JoVE · 2025Article
- Cross-modal sensory compensation increases mosquito attraction to humans.Science advances · 2025Article
- Ectopic taste receptors in animal physiology: evolutionary conservation and functional diversification.Frontiers in cell and developmental biology · 2025Review
- Article
- Gut tumors in flies alter the taste valence of an anti-tumorigenic bitter compound.Current biology : CB · 2024Article
- Extra-corporeal detoxification in insects.Heliyon · 2024Article
- Base Recording: A Technique for Analyzing Responses of Taste Neurons in Drosophila.Journal of visualized experiments : JoVE · 2024Article
- Taste evolution in an herbivorous drosophilid.bioRxiv : the preprint server for biology · 2024Article
- Evolution of chemosensory tissues and cells across ecologically diverse Drosophilids.Nature communications · 2024Article
- Diabetic sensory neuropathy and insulin resistance are induced by loss of UCHL1 in Drosophila.Nature communications · 2024Article
41 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
To understand the principles of taste coding, it is necessary to understand the functional organization of the taste organs. Although the labellum of the Drosophila melanogaster head has been described in detail, the tarsal segments of the legs, which collectively contain more taste sensilla than the labellum, have received much less attention. We performed a systematic anatomical, physiological, and molecular analysis of the tarsal sensilla of Drosophila. We construct an anatomical map of all five tarsal segments of each female leg. The taste sensilla of the female foreleg are systematically tested with a panel of 40 diverse compounds, yielding a response matrix of ∼500 sensillum-tastant combinations. Six types of sensilla are characterized. One type was tuned remarkably broadly: it responded to 19 of 27 bitter compounds tested, as well as sugars; another type responded to neither. The midleg is similar but distinct from the foreleg. The response specificities of the tarsal sensilla differ from those of the labellum, as do n-dimensional taste spaces constructed for each organ, enhancing the capacity of the fly to encode and respond to gustatory information. We examined the expression patterns of all 68 gustatory receptors (Grs). A total of 28 Gr-GAL4 drivers are expressed in the legs. We constructed a receptor-to-sensillum map of the legs and a receptor-to-neuron map. Fourteen Gr-GAL4 drivers are expressed uniquely in the bitter-sensing neuron of the sensillum that is tuned exceptionally broadly. Integration of the molecular and physiological maps provides insight into the underlying basis of taste coding.
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