ArticleJournal of critical care2014
Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults.
Article in Journal of critical care, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Interleukin-27 as a Diagnostic Biomarker for Patients with Sepsis: A Meta-Analysis.BioMed research international · 2021Pooled it
- Interleukin-27: a novel biomarker in predicting bacterial infection among the critically ill.Critical care (London, England) · 2015Trial
- IL-27 regulates macrophage ferroptosis by inhibiting the Nrf2/HO1 signaling pathway in sepsis-induced ARDS.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Inhibition of IL-27 signaling regulates chemokine levels and sustains CXCR2 receptor expression on mononuclear cells to improve disease outcomes during gram-negative neonatal sepsis.Frontiers in immunology · 2025Article
- Role of IL-27 in COVID-19: A Thin Line between Protection and Disease Promotion.International journal of molecular sciences · 2024Review
- Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation.Bone research · 2022Article
- The IL-27 receptor regulates TIGIT on memory CD4iScience · 2021Article
- Interleukin-27 and Its Diverse Effects on Bacterial Infections.Frontiers in immunology · 2021Review
- Biomarkers of sepsis: time for a reappraisal.Critical care (London, England) · 2020Review
- Sepsis Biomarkers.Journal of pediatric intensive care · 2019Review
- Point of care technologies for sepsis diagnosis and treatment.Lab on a chip · 2019Review
- IL-17, IL-27, and IL-33: A Novel Axis Linked to Immunological Dysfunction During Sepsis.Frontiers in immunology · 2019Review
- Interleukin-27 as a candidate diagnostic biomarker for bacterial infection in immunocompromised pediatric patients.PloS one · 2018Article
- Emerging infection and sepsis biomarkers: will they change current therapies?Expert review of anti-infective therapy · 2016Review
- Interleukin-18 and miR-130a in severe sepsis patients with thrombocytopenia.Patient preference and adherence · 2016Article
- Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Biomarkers of sepsis and their potential value in diagnosis, prognosis and treatment.Expert review of clinical immunology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
purposeWe recently identified interleukin-27 (IL-27) as a sepsis diagnostic biomarker in children. Here we assess IL-27 as a sepsis diagnostic biomarker in critically ill adults with systemic inflammatory response syndrome and sepsis.
methodsIL-27 and procalcitonin (PCT) were measured from plasma samples in three groups: no sepsis (n = 78), pulmonary source of sepsis (n = 66), and non-pulmonary source of sepsis (n = 43). Receiver operating characteristic curves and classification and regression tree methodology were used to evaluate biomarker performance.
resultsIL-27 did not discriminate effectively between sepsis and sterile systemic inflammatory response syndrome in unselected patients. The highest area under the curve (AUC) was 0.70 (95% C.I. 0.60 - 0.80) for IL-27 in subjects with a non-pulmonary source of sepsis. A decision tree incorporating IL-27, PCT, and age had an AUC of 0.79 (0.71-0.87) in subjects with a non-pulmonary source of sepsis. Compared to children with sepsis, adults with sepsis express less IL-27.
conclusionsIL-27 performed overall poorly in this cohort as a sepsis diagnostic biomarker. Combining IL-27, PCT, and age reasonably estimated the risk of sepsis in subjects with a non-pulmonary source of sepsis. IL-27 may be a more reliable sepsis diagnostic biomarker in children than in adults.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.