ArticleAnalytical chemistry2014
Two-photon antenna-core oxygen probe with enhanced performance.
Article in Analytical chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications.Chemical reviews · 2024Review
- Biocompatible Phosphorescent OBiosensors · 2023Article
- The Challenges of OInternational journal of molecular sciences · 2022Review
- Measurement of cerebral oxygen pressure in living mice by two-photon phosphorescence lifetime microscopy.STAR protocols · 2022Article
- Novel NIR-Phosphorescent Ir(III) Complexes: Synthesis, Characterization and Their Exploration as Lifetime-Based OMolecules (Basel, Switzerland) · 2022Article
- Neurophotonic tools for microscopic measurements and manipulation: status report.Neurophotonics · 2022Article
- Biocompatible Ir(III) Complexes as Oxygen Sensors for Phosphorescence Lifetime Imaging.Molecules (Basel, Switzerland) · 2021Article
- Article
- Two-Photon Phosphorescence Lifetime Microscopy.Advances in experimental medicine and biology · 2021Article
- In vivo OScientific reports · 2020Article
- Inhibition of Oxidative Phosphorylation Reverses Bone Marrow Hypoxia Visualized in Imageable Syngeneic B-ALL Mouse Model.Frontiers in oncology · 2020Article
- Electrospun Fiber Mesh for High-Resolution Measurements of Oxygen Tension in Cranial Bone Defect Repair.ACS applied materials & interfaces · 2019Article
- Merger of dynamic two-photon and phosphorescence lifetime microscopy reveals dependence of lymphocyte motility on oxygen in solid and hematological tumors.Journal for immunotherapy of cancer · 2019Article
- Oxyphor 2P: A High-Performance Probe for Deep-Tissue Longitudinal Oxygen Imaging.Cell metabolism · 2019Article
- New red-emitting Schiff base chelates: promising dyes for sensing and imaging of temperature and oxygenJournal of materials chemistry. C · 2018Article
- Chromophore-Functionalized Phenanthro-diimine Ligands and Their Re(I) Complexes.Inorganic chemistry · 2018Article
- Fluorescence lifetime microscopy of NADH distinguishes alterations in cerebral metabolismBiomedical optics express · 2017Article
- Bright long-lived luminescence of silicon nanocrystals sensitized by two-photon absorbing antenna.Chem · 2017Article
- Two-Photon Absorbing Phosphorescent Metalloporphyrins: Effects of π-Extension and Peripheral Substitution.Journal of the American Chemical Society · 2016Article
- Phosphorescent soft salt for ratiometric and lifetime imaging of intracellular pH variations.Chemical science · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Recent development of two-photon phosphorescence lifetime microscopy (2PLM) of oxygen enabled first noninvasive high-resolution measurements of tissue oxygenation in vivo in 3D, providing valuable physiological information. The so far developed two-photon-enhanced phosphorescent probes comprise antenna-core constructs, in which two-photon absorbing chromophores (antenna) capture and channel excitation energy to a phosphorescent core (metalloporphyrin) via intramolecular excitation energy transfer (EET). These probes allowed demonstration of the methods' potential; however, they suffer from a number of limitations, such as partial loss of emissivity to competing triplet state deactivation pathways (e.g., electron transfer) and suboptimal sensitivity to oxygen, thereby limiting spatial and temporal resolution of the method. Here we present a new probe, PtTCHP-C307, designed to overcome these limitations. The key improvements include significant increase in the phosphorescence quantum yield, higher efficiency of the antenna-core energy transfer, minimized quenching of the phosphorescence by electron transfer and increased signal dynamic range. For the same excitation flux, the new probe is able to produce up to 6-fold higher signal output than previously reported molecules. Performance of PtTCHP-C307 was demonstrated in vivo in pO2 measurements through the intact mouse skull into the bone marrow, where all blood cells are made from hematopoietic stem cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.