ArticlePloS one2014
Additive effect between IL-13 polymorphism and cesarean section delivery/prenatal antibiotics use on atopic dermatitis: a birth cohort study (COCOA).
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Prenatal maternal antibiotic use increases the risk of childhood eczema: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Maternal exposure to antibiotics increases the risk of infant eczema before one year of life: a meta-analysis of observational studies.World journal of pediatrics : WJP · 2020Pooled it
- How informative is the mouse for human gut microbiota research?Disease models & mechanisms · 2015Pooled it
- Maternal exposures and the infant gut microbiome: a systematic review with meta-analysis.Gut microbesPooled it
- Trial
- Umbilical Cord Blood Biomarkers for Early Risk Stratification of Childhood Asthma and Atopic Dermatitis: A Developmental and Critical Appraisal.Journal of asthma and allergy · 2026Review
- Protocol design for the ACTIVATE clinical trial: Exposure to vaginal microbiome in cesarean-delivered infants at high risk for allergies.The journal of allergy and clinical immunology. Global · 2025Article
- Article
- Allergy-associated biomarkers in early life identified by Omics techniques.Frontiers in allergy · 2024Review
- Association between gut microbiota and pan-dermatological diseases: a bidirectional Mendelian randomization research.Frontiers in cellular and infection microbiology · 2024Article
- Effect of partially hydrolyzed synbiotic formula milk on weight gain of late preterm and term infants-a multicenter study.Frontiers in pediatrics · 2023Article
- Maternal exposure to antibiotics and risk of atopic dermatitis in childhood: a systematic review and meta-analysis.Frontiers in pediatrics · 2023Review
- A cohort study of intrapartum group B streptococcus prophylaxis on atopic dermatitis in 2-year-old children.BMC pediatrics · 2022Article
- Grape seed and skin extract, a potential prebiotic with anti-obesity effect through gut microbiota modulation.Gut pathogens · 2022Article
- Clinical efficacy of fecal microbial transplantation treatment in adults with moderate-to-severe atopic dermatitis.Immunity, inflammation and disease · 2022Article
- D-galactose Intake Alleviates Atopic Dermatitis in Mice by Modulating Intestinal Microbiota.Frontiers in nutrition · 2022Article
- Interactions BetweenAllergy, asthma & immunology research · 2021Article
- How do Host Genetic Factors Affect Gut Microbiome in the Development of Atopic Dermatitis?Allergy, asthma & immunology research · 2021Article
- Comprehensive Analysis of the Effect of Probiotic Intake by the Mother on Human Breast Milk and Infant Fecal Microbiota.Journal of Korean medical science · 2021Article
- Early life microbial exposures and allergy risks: opportunities for prevention.Nature reviews. Immunology · 2021Review
Corrections and comments
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Authors and funding
28 authors at 13 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough cesarean delivery and prenatal exposure to antibiotics are likely to affect the gut microbiome in infancy, their effect on the development of atopic dermatitis (AD) in infancy is unclear. The influence of individual genotypes on these relationships is also unclear. To evaluate with a prospective birth cohort study whether cesarean section, prenatal exposure to antibiotics, and susceptible genotypes act additively to promote the development of AD in infancy.
methodsThe Cohort for Childhood of Asthma and Allergic Diseases (COCOA) was selected from the general Korean population. A pediatric allergist assessed 412 infants for the presence of AD at 1 year of age. Their cord blood DNA was subjected to interleukin (IL)-13 (rs20541) and cluster-of-differentiation (CD)14 (rs2569190) genotype analysis.
resultsThe combination of cesarean delivery and prenatal exposure to antibiotics associated significantly and positively with AD (adjusted odds ratio, 5.70; 95% CI, 1.19-27.3). The association between cesarean delivery and AD was significantly modified by parental history of allergic diseases or risk-associated IL-13 (rs20541) and CD14 (rs2569190) genotypes. There was a trend of interaction between IL-13 (rs20541) and delivery mode with respect to the subsequent risk of AD. (P for interaction = 0.039) Infants who were exposed prenatally to antibiotics and were born by cesarean delivery had a lower total microbiota diversity in stool samples at 6 months of age than the control group. As the number of these risk factors increased, the AD risk rose (trend p<0.05).
conclusionCesarean delivery and prenatal antibiotic exposure may affect the gut microbiota, which may in turn influence the risk of AD in infants. These relationships may be shaped by the genetic predisposition.
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