ArticleJournal of neurophysiology2014
Long-term deficits in motion detection thresholds and spike count variability after unilateral vestibular lesion.
Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Review
- How Peripheral Vestibular Damage Affects Velocity Storage: a Causative Explanation.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Vestibular Precision at the Level of Perception, Eye Movements, Posture, and Neurons.Neuroscience · 2021Review
- Vestibular processing during natural self-motion: implications for perception and action.Nature reviews. Neuroscience · 2019Review
- Improvement of Mechanical Stability for Single Unit Recording Based on Skull Cap in Living Chinchilla.Current medical science · 2019Article
- Article
- Plasticity within excitatory and inhibitory pathways of the vestibulo-spinal circuitry guides changes in motor performance.Scientific reports · 2017Article
- Reviewing the Role of the Efferent Vestibular System in Motor and Vestibular Circuits.Frontiers in physiology · 2017Review
- Self-motion evokes precise spike timing in the primate vestibular system.Nature communications · 2016Article
- Responses of non-eye-movement central vestibular neurons to sinusoidal yaw rotation in compensated macaques after unilateral semicircular canal plugging.Journal of neurophysiology · 2016Article
- Correlation between afferent rearrangements and behavioral deficits after local excitotoxic insult in the mammalian vestibule: a rat model of vertigo symptoms.Disease models & mechanisms · 2016Article
- Plasticity within non-cerebellar pathways rapidly shapes motor performance in vivo.Nature communications · 2016Article
- Loss of Afferent Vestibular Input Produces Central Adaptation and Increased Gain of Vestibular Prosthetic Stimulation.Journal of the Association for Research in Otolaryngology : JARO · 2016Article
- Neuronal thresholds and choice-related activity of otolith afferent fibers during heading perception.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Coding of envelopes by correlated but not single-neuron activity requires neural variability.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The vestibular system operates in a push-pull fashion using signals from both labyrinths and an intricate bilateral organization. Unilateral vestibular lesions cause well-characterized motor deficits that are partially compensated over time and whose neural correlates have been traced in the mean response modulation of vestibular nuclei cells. Here we compare both response gains and neural detection thresholds of vestibular nuclei and semicircular canal afferent neurons in intact vs. unilateral-lesioned macaques using three-dimensional rotation and translation stimuli. We found increased stimulus-driven spike count variability and detection thresholds in semicircular canal afferents, although mean responses were unchanged, after contralateral labyrinth lesion. Analysis of trial-by-trial spike count correlations of a limited number of simultaneously recorded pairs of canal afferents suggests increased noise correlations after lesion. In addition, we also found persistent, chronic deficits in rotation detection thresholds of vestibular nuclei neurons, which were larger in the ipsilesional than the contralesional brain stem. These deficits, which persisted several months after lesion, were due to lower rotational response gains, whereas spike count variability was similar in intact and lesioned animals. In contrast to persistent deficits in rotation threshold, translation detection thresholds were not different from those in intact animals. These findings suggest that, after compensation, a single labyrinth is sufficient to recover motion sensitivity and normal thresholds for the otolith, but not the semicircular canal, system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.