ArticleThe Journal of membrane biology2014
Affinity of alkylphosphocholines to biological membrane of prostate cancer: studies in natural and model systems.
Article in The Journal of membrane biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Stability and Compressibility of Tear Film Lipid Layer: Impact of Benzalkonium Chloride Presence.bioRxiv : the preprint server for biology · 2026Article
- Molecular Mechanisms of Action of Dendrimers with Antibacterial Activities on Model Lipid Membranes.Polymers · 2025Article
- Floating Films of Biological Importance at the Liquid-Gas Interface: Langmuir Monolayer Approach.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Advantages of the classical thermodynamic analysis of single-and multi-component Langmuir monolayers from molecules of biomedical importance-theory and applications.Journal of the Royal Society, Interface · 2024Review
- Interaction of different lipoprotein types with cholesterol at the air/water interface.Heliyon · 2020Article
- Study of the Mechanism of the Antimicrobial Activity of Novel Water Soluble Ammonium Quaternary Benzanthrone on Model Membranes.The Journal of membrane biology · 2020Article
- Effect of Erufosine on Membrane Lipid Order in Breast Cancer Cell Models.Biomolecules · 2020Article
- Oxysterols Versus Cholesterol in Model Neuronal Membrane. I. The Case of 7-Ketocholesterol. The Langmuir Monolayer Study.The Journal of membrane biology · 2017Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effectiveness of two alkylphosphocholines (APCs), hexadecylphosphocholine (miltefosine) and erucylphosphocholine to combat prostate cancer has been studied in vitro with artificial cancerous membrane, modelled with the Langmuir monolayer technique, and on cell line (Du-145). Studies performed with the Langmuir method indicate that both the investigated drugs have the affinity to the monolayer mimicking prostate cancer membrane (composed of cholesterol:POPC = 0.428) and the drug-membrane interactions are stronger for erucylphosphocholine as compared to hexadecylphosphocholine. Moreover, both studied drugs were found to fluidize the model membrane, which may lead to apoptosis. Indeed, biological studies confirmed that in Du-145 cell line both investigated alkylphosphocholines cause cell death primarily by apoptosis while necrotic cells constitute only a small percentage of APC-treated cells.
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