ArticlePloS one2014
FGF21 promotes endothelial cell angiogenesis through a dynamin-2 and Rab5 dependent pathway.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- New developments in the biology of fibroblast growth factors.WIREs mechanisms of disease · 2022Review
- Spontaneous Browning of White Adipose Tissue Improves Angiogenesis and Reduces Macrophage Infiltration After Fat Grafting in Mice.Frontiers in cell and developmental biology · 2022Article
- The role of FGF21 in the pathogenesis of cardiovascular disease.Chinese medical journal · 2021Review
- Tubulin carboxypeptidase activity of vasohibin-1 inhibits angiogenesis by interfering with endocytosis and trafficking of pro-angiogenic factor receptors.Angiogenesis · 2021Article
- GIPC-Regulated IGFBP-3 Promotes HSC Migration In Vitro and Portal Hypertension In Vivo Through a β1-Integrin Pathway.Cellular and molecular gastroenterology and hepatology · 2020Article
- FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival.Cell death & disease · 2019Article
- Association between Circulating Fibroblast Growth Factor 21 and Aggressiveness in Thyroid Cancer.Cancers · 2019Article
- MiRNA-575 suppresses angiogenesis by targeting Rab5-MEK-ERK pathway in endothelial cells.Bioscience reports · 2019Article
- FGF21 trafficking in intact human cells revealed by cryo-electron tomography with gold nanoparticles.eLife · 2019Article
- FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice.Cell reports · 2017Article
- Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration.The American journal of pathology · 2017Article
- Valproic Acid and Other HDAC Inhibitors Upregulate FGF21 Gene Expression and Promote Process Elongation in Glia by Inhibiting HDAC2 and 3.The international journal of neuropsychopharmacology · 2016Article
- Exosome Adherence and Internalization by Hepatic Stellate Cells Triggers Sphingosine 1-Phosphate-dependent Migration.The Journal of biological chemistry · 2015Article
- Fibroblast growth factors in cardiovascular disease: The emerging role of FGF21.American journal of physiology. Heart and circulatory physiology · 2015Review
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Authors and funding
6 authors.
Funding
Abstract
Binding of angiogenic molecules with cognate receptor tyrosine kinases (RTK) is required for angiogenesis however the precise link between RTK binding, endocytosis, and signaling requires further investigation. Here, we use FGFR1 as a model to test the effects of the large GTPase and endocytosis regulatory molecule dynamin-2 on angiogenic signaling in context of distinct FGF ligands. In vitro, overexpression of dominant negative dynamin-2 (DynK44A) attenuates FGFR1 activation of Erk and tubulogenesis by FGF2. Furthermore, we identify FGF21, a non-classical, FGF ligand implicated in diverse human pathologies as an angiogenic molecule acting through FGFR1 and β-Klotho coreceptor. Disruption of FGFR1 activation of ERK by FGF21 is achieved by perturbation of the function of both dynamin-2 and Rab5 GTPase. In vivo, mice harboring endothelial selective overexpression of DynK44A, show impaired angiogenesis in response to FGF21. In conclusion, dynamin dependent endocytosis of FGFR1 is required for in vitro and in vivo angiogenesis in response to FGF2 and the non-classical FGF ligand, FGF21. These studies extend our understanding of the relationships between RTK binding, internalization, endosomal targeting, and angiogenic signaling.
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