ArticlePloS one2014
SSRIs increase risk of blood transfusion in patients admitted for hip surgery.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 30 citations in OpenAlex.
- Systematic Review on Antidepressant Use and Bleeding Risk After Dental Extractions: Evidence Gaps and Clinical Implications.Journal of clinical medicine · 2025Review
- Association between selective serotonin reuptake inhibitors use and blood transfusion risk in older adults after hip fracture: a cohort study.BMC geriatrics · 2024Observational
- Preoperative SSRI use increases perioperative transfusion need in patients undergoing surgical procedures on the hip joint.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Article
- A matched-control study on the effects of depressive disorders following open reduction and internal fixation for acetabular fractures.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2022Article
- Serotonin reuptake inhibitors and bleeding risks related to elderly submitted to major orthopedic surgery.Einstein (Sao Paulo, Brazil) · 2019Article
- SSRI co-medication with NOAC or VKA does not increase hospitalisation for bleeding: A retrospective nationwide cohort study in Austria 2010-2015.International journal of geriatric psychiatry · 2019Article
- Article
- Selective Serotonin Reuptake Inhibitors and Operative Bleeding Risk: A Review of the Literature.Journal of clinical psychopharmacology · 2016Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies have shown that an increased bleeding tendency can be caused by Selective Serotonin Reuptake Inhibitors (SSRI) use. We aimed to investigate the occurrence and risk of blood transfusion in SSRI users compared to non-SSRI users in a cohort of patients admitted for hip-surgery.
methodsWe conducted a retrospective cohort study of patients who underwent planned or emergency hip surgery from 1996 to 2011 in the Academic Medical Center in Amsterdam. Primary outcome measure was risk of blood transfusion. Secondary outcome measures were pre- and postoperative hemoglobin level. Multivariate logistic regression was used to adjust for potential confounders.
resultsOne-hundred and fourteen SSRI users were compared to 1773 non-SSRI users. Risk of blood transfusion during admission was increased for SSRI users in multivariate analyses (OR 1.7 [95% CI 1.1-2.5]). Also, pre-operative hemoglobin levels were lower in SSRI users (7.8 ± 1.0 mmol/L) compared to non-SSRI users (8.0 ± 1.0 mmol/L) (p = 0.042)), as were postoperative hemoglobin levels (6.2 ± 1.0 mmol/L vs. 6.4 ± 1.0 mmol/L respectively) (p = 0.017)).
conclusionsSSRI users undergoing hip surgery have an increased risk for blood transfusion during admission, potentially explained by a lower hemoglobin level before surgery. SSRI use should be considered as a potential risk indicator for increased blood loss in patients admitted for hip surgery. These results need to be confirmed in a prospective study.
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