ArticleACS synthetic biology2015
Design and implementation of a biomolecular concentration tracker.
Article in ACS synthetic biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Multi-Layer Autocatalytic Feedback Enables Integral Control Amidst Resource Competition and Across Scales.ACS synthetic biology · 2025Article
- A hybrid in silico/in-cell controller that handles process-model mismatches using intracellular biosensing.Scientific reports · 2024Article
- Regulation strategies for two-output biomolecular networks.Journal of the Royal Society, Interface · 2023Article
- A cybergenetic framework for engineering intein-mediated integral feedback control systems.Nature communications · 2023Article
- Frequency spectra and the color of cellular noise.Nature communications · 2022Article
- A hierarchy of biomolecular proportional-integral-derivative feedback controllers for robust perfect adaptation and dynamic performance.Nature communications · 2022Article
- Dichotomous feedback: a signal sequestration-based feedback mechanism for biocontroller design.Journal of the Royal Society, Interface · 2022Article
- Control of mammalian cell-based devices with genetic programming.Current opinion in systems biology · 2021Article
- Context-aware synthetic biology by controller design: Engineering the mammalian cell.Cell systems · 2021Review
- Programmable protein circuit design.Cell · 2021Review
- Quasi-robust control of biochemical reaction networks via stochastic morphing.Journal of the Royal Society, Interface · 2021Article
- Autonomous and Assisted Control for Synthetic Microbiology.International journal of molecular sciences · 2020Review
- Article
- Architectural Principles for Characterizing the Performance of Antithetic Integral Feedback Networks.iScience · 2019Article
- A quasi-integral controller for adaptation of genetic modules to variable ribosome demand.Nature communications · 2018Article
- Synthetic negative feedback circuits using engineered small RNAs.Nucleic acids research · 2018Article
- Antithetic proportional-integral feedback for reduced variance and improved control performance of stochastic reaction networks.Journal of the Royal Society, Interface · 2018Article
- Design of an embedded inverse-feedforward biomolecular tracking controller for enzymatic reaction processes.Computers & chemical engineering · 2017Article
- Modeling the architecture of the regulatory system controlling methylenomycin production inJournal of biological engineering · 2017Article
- Control theory meets synthetic biology.Journal of the Royal Society, Interface · 2016Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
As a field, synthetic biology strives to engineer increasingly complex artificial systems in living cells. Active feedback in closed loop systems offers a dynamic and adaptive way to ensure constant relative activity independent of intrinsic and extrinsic noise. In this work, we use synthetic protein scaffolds as a modular and tunable mechanism for concentration tracking through negative feedback. Input to the circuit initiates scaffold production, leading to colocalization of a two-component system and resulting in the production of an inhibitory antiscaffold protein. Using a combination of modeling and experimental work, we show that the biomolecular concentration tracker circuit achieves dynamic protein concentration tracking in Escherichia coli and that steady state outputs can be tuned.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.