ArticleEuropean thyroid journal2013
Positive cytology findings and a negative histological diagnosis of papillary thyroid carcinoma in the thyroid: is it a false-positive cytology or a disappearing tumor?
Article in European thyroid journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- In suspicious for malignancy thyroid nodule aspirates, nuclei characteristics deserves special attention in reported cytology analysis - real world scenario cohort.Archives of endocrinology and metabolism · 2025Article
- Cytohistological Correlation of Thyroid Cases with Emphasis on Papillary Thyroid Carcinoma and Analysis of the Causes of Diagnostic Errors on Cytology.Turk patoloji dergisi · 2025Article
- Metastatic Disease to a Concurrent Thyroid Neoplasm: A Case Series and Review of the Literature.Head and neck pathology · 2023Review
- Comparison between ultrasonographic findings and fine needle aspiration cytology in differentiating malignant and benign thyroid nodules.European journal of translational myology · 2019Article
- Detection of BRAF V600E Mutations With Next-Generation Sequencing in Infarcted Thyroid Carcinomas After Fine-Needle Aspiration.American journal of clinical pathology · 2018Article
- Malignant-looking thyroid nodules with size reduction: core needle biopsy results.Ultrasonography (Seoul, Korea) · 2016Article
- Vanishing tumors of thyroid: histological variations after fine needle aspiration.Gland surgery · 2016Article
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11 authors.
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Abstract
backgroundIt infrequently occurs that cytologic diagnosis of papillary thyroid carcinoma (PTC) cannot be confirmed by histology after surgery. This phenomenon may be a false-positive cytology or a true disappearing tumor.
objectivesWe evaluated patients who had consistent findings of PTC at fine needle aspiration cytology (FNAC) and no evidence of PTC in surgical specimens.
methodsPositive cytology findings and a negative histological diagnosis of PTC in the thyroid was defined as thyroid nodules with FNAC findings of PTC prior to surgery and no evidence of malignancy on histological examination of surgically removed thyroids. We retrospectively reviewed patients who underwent fine needle aspiration (FNA) and thyroidectomy in Asan Medical Center from 2004 to 2012.
resultsSix patients were found who fit the definition of positive cytology findings and a negative histological diagnosis of PTC in the thyroid. The FNAC diagnosis of 6 patients was 'malignancy ' suggesting PTC according to the Bethesda system. All patients underwent thyroidectomy with central neck dissection. Three patients had reactive changes after FNA due to needle passage. Among these 3 patients, 2 had pathologically confirmed metastatic PTC in dissected lymph nodes. These 2 patients could be defined as true disappearing PTC in the thyroid after FNA. The remaining 3 patients had neither histologic alterations nor evidence of PTC in the thyroid and lymph nodes specimens.
conclusionsBoth disappearing PTC and a false-positive result of FNAC should be considered in patients with positive cytology findings and a negative histological diagnosis of PTC in the thyroid.
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