Evidence map›Paper›PMID 24847445›Full record

ArticleFrontiers in oncology2014

Human Pancreatic Cancer-Associated Stellate Cells Remain Activated after in vivo Chemoradiation.

M Carla Cabrera, Estifanos Tilahun, Rebecca Nakles, Edgar S Diaz-Cruz, Aline Charabaty, Simeng Suy, Patrick Jackson, Lisa Ley, Rebecca Slack, Reena Jha and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. FAK inhibition radiosensitizes pancreatic ductal adenocarcinoma cells in vitro.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2021
    Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Pancreatic cancer: A multipronged approach to pancreatic cancer treatment.Nature reviews. Gastroenterology & hepatology · 2016
    Article
  15. Article
  16. Review
  17. Cancer stem cell plasticity and tumor hierarchy.World journal of stem cells · 2015
    Review
  18. Review
  19. Microenvironment in determining chemo-resistance in pancreatic cancer: Neighborhood matters.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

M Carla CabreraNational Cancer Informatics Program, National Cancer Institute, National Institutes of Health , Bethesda, MD , USA ; Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University , Washington, DC , USA.
Estifanos TilahunLombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University , Washington, DC , USA.
Rebecca NaklesLombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University , Washington, DC , USA.
Edgar S Diaz-CruzLombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University , Washington, DC , USA ; Department of Pharmaceutical Sciences, College of Pharmacy, Belmont University , Nashville, TN , USA.
Aline CharabatyDepartment of Gastroenterology, Georgetown University , Washington, DC , USA.
Simeng SuyLombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University , Washington, DC , USA ; Department of Radiation Medicine, Georgetown University , Washington, DC , USA.
Patrick JacksonDepartment of Surgery, Georgetown University , Washington, DC , USA.
Lisa LeyLombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University , Washington, DC , USA.
Rebecca SlackDepartment of Biostatistics, University of Texas MD Anderson Cancer Center , Houston, TX , USA.
Reena JhaDepartment of Radiology, Georgetown University , Washington, DC , USA.
Sean P CollinsLombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University , Washington, DC , USA ; Department of Radiation Medicine, Georgetown University , Washington, DC , USA.
Nadim HaddadDepartment of Gastroenterology, Georgetown University , Washington, DC , USA.
Bhaskar V S KallakuryLombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University , Washington, DC , USA ; Department of Pathology, Georgetown University , Washington, DC , USA.
Timm SchroederHelmholtz Zentrum München - German Research Center for Environmental Health, Research Unit Stem Cell Dynamics , Neuherberg , Germany ; Department of Biosystems Science and Engineering, ETH Zurich , Basel , Switzerland.
Michael J PishvaianLombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University , Washington, DC , USA ; Department of Gastroenterology, Georgetown University , Washington, DC , USA ; Division of Hematology/Oncology, Department of Medicine, Georgetown University , Washington, DC , USA.
Priscilla A FurthLombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University , Washington, DC , USA ; Division of Hematology/Oncology, Department of Medicine, Georgetown University , Washington, DC , USA.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI Louis M Weiner · 1990 to 2026
$71.5M
TRAINING GRANT IN TUMOR BIOLOGYT32CA009686 · NCI · GEORGETOWN UNIVERSITY · PI ANNA Tate RIEGEL, DAVID J ROBBINS · 1996 to 2026
$10.8M
MECHANISMS REGULATING REVERSAL OF PREMALIGNANCYR01CA089041 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI FURTH, PRISCILLA A. · 2001 to 2009
$2.0M
NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA051008NCI NIH HHS R01 CA089041NCI NIH HHS T32 CA009686
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive fibrotic reaction or desmoplasia and complex involvement of the surrounding tumor microenvironment. Pancreatic stellate cells are a key mediator of the pancreatic matrix and they promote progression and invasion of pancreatic cancer by increasing cell proliferation and offering protection against therapeutic interventions. Our study utilizes human tumor-derived pancreatic stellate cells (HTPSCs) isolated from fine needle aspirates of pancreatic cancer tissue from patients with locally advanced, unresectable pancreatic adenocarcinoma before and after treatment with full-dose gemcitabine plus concurrent hypo-fractionated stereotactic radiosurgery. We show that HTPSCs survive in vivo chemotherapy and radiotherapy treatment and display a more activated phenotype post-therapy. These data support the idea that stellate cells play an essential role in supporting and promoting pancreatic cancer and further research is needed to develop novel treatments targeting the pancreatic tumor microenvironment.

Indexed as

chemotherapygemcitabinepancreatic cancerPDACradiationstellate cells

Identifiers

PMID24847445
PMCPMC4023027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.