ArticleIranian journal of basic medical sciences2014
Immunohistochemical study of type III collagen expression during pre and post-natal rat skin morphogenesis.
Article in Iranian journal of basic medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Gremlin 2 suppresses differentiation of stem/progenitor cells in the human skin.Regenerative therapy · 2021Article
- Hyperbaric oxygen enhances collagen III formation in wound of ZDF rat.Physiological research · 2021Article
- Extra Cellular Matrix Deposition and Assembly in Dermis Spheroids.Clinical, cosmetic and investigational dermatology · 2021Article
- The effect of titanium dioxide nanoparticles on mice midbrain substantia nigra.Iranian journal of basic medical sciences · 2019Article
- Effect of methamphetamine exposure during pregnancy and lactation on polysialic acid-neural cell adhesion molecule expression in rat's offspring hippocampus.Metabolic brain disease · 2017Article
- Comparative Analysis of the Extracellular Matrix Composition in Proliferating and Involuted Infantile Hemangiomas.Archives of plastic surgery · 2015Article
- Decellularized kidney in the presence of chondroitin sulfate as a natural 3D scaffold for stem cells.Iranian journal of basic medical sciences · 2015Article
- Inhibition of Pseudomonas aeruginosa biofilm formation by 2,2'-bipyridyl, lipoic, kojic and picolinic acids.Iranian journal of basic medical sciences · 2015Article
- Glycoconjugates distribution during developing mouse spinal cord motor organizers.Iranian biomedical journal · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE(S): Skin extracellular matrix, which contains type I and type III collagens, is involved in skin development. The aim of this study was to investigate type III collagen distribution pattern as well as its changes during pre and post-natal skin morphogenesis in rats. MATERIALS AND
methodsVentral skins of Wistar rat embryos at different stages from 10 to 20 gestational day (E10-E20) and also one month and one year post natal rat pups were fixed in normalin, embedded in paraffin and 5 µm thick sections were incubated with Anti type III collagen antibody. In order to detect staining intensity, the reactions were observed and graded by three examiners separately. Kruskal-Wallis non-parametric statistical test and SPSS software version 11.5 were used to compare differences between samples.
resultsImmunoreactivity of type III collagen was distributed weakly in the mesenchymal connective tissue on day 10 (E10). The observed reaction was increased onE12 and E14. This reaction was clear in basement membrane, relatively intensive in dermal papillae and moderate in dermal reticularis on E14. This immunoreactivity pattern was increased afterward on E16, not changed on E18 and decreased in dermal reticularis on E20. The density of collagen type III in dermal papillae and dermal reticularis in skin of one year old rats were decreased comparing to one month old rats.
conclusionOur results showed that type III collagen is expressed and timely regulated during pre and post natal rat skin morphogenesis.
Indexed as
Identifiers
24847422PMC4016690W2108496851What OpenQuestion holds
Registered trials
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