ReviewFrontiers in endocrinology2014
Cytokines and Hormones That Contribute to the Positive Association between Fat and Bone.
Review in Frontiers in endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06594042 (Serum Preptin Level and Its Relationship With Bone Mineral Disease in Chronic Kidney Disease Patients), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Serum Preptin Level and Its Relationship With Bone Mineral Disease in Chronic Kidney Disease Patients
Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Greater inflammation and adiposity are associated with lower bone mineral density in youth with type 1 diabetes.Diabetes research and clinical practice · 2018Trial
- Understanding the Consequences of Fatty Bone and Fatty Muscle: How the Osteosarcopenic Adiposity Phenotype Uncovers the Deterioration of Body Composition.Metabolites · 2023Review
- Preptin: A New Bone Metabolic Parameter?Metabolites · 2023Review
- Age, body composition parameters and glycaemic control contribute to trabecular bone score deterioration in acromegaly more than disease activity.Frontiers in endocrinology · 2023Article
- The associations between body fat distribution and bone mineral density in the Oxford Biobank: a cross sectional study.Expert review of endocrinology & metabolism · 2022Article
- Bone Response to Weight Loss Following Bariatric Surgery.Frontiers in endocrinology · 2022Review
- The Role of Osteoclast Energy Metabolism in the Occurrence and Development of Osteoporosis.Frontiers in endocrinology · 2021Review
- Low muscle mass and body composition analysis in a group of postmenopausal women affected by primary Sjögren's syndrome.Reumatologia · 2021Article
- Sarcopenia negatively affects hip structure analysis variables in a group of Lebanese postmenopausal women.BMC bioinformatics · 2020Article
- Assessment of Preptin peptide level in the sera of rachitic children and in breast milk of their mothers.Italian journal of pediatrics · 2019Article
- Amylin in Alzheimer's disease: Pathological peptide or potential treatment?Neuropharmacology · 2018Review
- Bone Health following Bariatric Surgery: Implications for Management Strategies to Attenuate Bone Loss.Advances in nutrition (Bethesda, Md.) · 2018Review
- A cross-sectional study of the association between adipokine levels and bone mineral density according to obesity and menopausal status in Korean women.Journal of bone and mineral metabolism · 2017Article
- Changes in body composition and metabolic profile during interleukin 6 inhibition in rheumatoid arthritis.Journal of cachexia, sarcopenia and muscle · 2017Article
- Bariatric Roux-En-Y Gastric Bypass Surgery: Adipocyte Proteins Involved in Increased Bone Remodeling in Humans.Obesity surgery · 2017Observational
- Bone Marrow Adipose Tissue: To Be or Not To Be a Typical Adipose Tissue?Frontiers in endocrinology · 2016Review
- Glucagon-like peptide-1(GLP-1) receptor agonists: potential to reduce fracture risk in diabetic patients?British journal of clinical pharmacology · 2016Review
- Increased body fat mass and tissue lipotoxicity associated with ovariectomy or high-fat diet differentially affects bone and skeletal muscle metabolism in rats.European journal of nutrition · 2015Article
- Obstructive sleep apnea and metabolic bone disease: insights into the relationship between bone and sleep.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The positive association between body weight and bone density has been established in numerous laboratory and clinical studies. Apart from the direct effect of soft tissue mass on bone through skeletal loading, a number of cytokines and hormones contribute to the positive association between adipose and bone tissue, acting either locally in sites where cells of the two tissues are adjacent to each other or systemically through the circulation. The current review describes the effects of such local and systemic factors on bone physiology. One class of factors are the adipocyte-secreted peptides (adipokines), which affect bone turnover through a combination of direct effects in bone cells and indirect mechanisms mediated by the central nervous system. Another source of hormones that contribute to the coupling between fat and bone tissue are beta cells of the pancreas. Insulin, amylin, and preptin are co-secreted from pancreatic beta cells in response to increased glucose levels after feeding, and are also found in high circulating levels in obesity. A number of peptide hormones secreted from the gastrointestinal tract in response to feeding affect both fat and bone cells and thus can also act as mediators of the association between the two tissues. The current review focuses on results of laboratory studies investigating possible mechanism involved in the positive association between fat mass and bone mass.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.