Evidence map›Paper›PMID 24847278›Full record

ArticleFrontiers in physiology2014

Habituation of Arctic ground squirrels (Urocitellus parryii) to handling and movement during torpor to prevent artificial arousal.

Sherri L Christian, Brian T Rasley, Tanna Roe, Jeanette T Moore, Michael B Harris, Kelly L Drew

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Sherri L ChristianDepartment of Chemistry and Biochemistry, Alaska Basic Neuroscience Program, Institute of Arctic Biology, University of Alaska Fairbanks Fairbanks, AK, USA ; Department of Biochemistry, Memorial University of Newfoundland St. John's, NL, Canada.
Brian T RasleyDepartment of Chemistry and Biochemistry, Alaska Basic Neuroscience Program, Institute of Arctic Biology, University of Alaska Fairbanks Fairbanks, AK, USA.
Tanna RoeDepartment of Chemistry and Biochemistry, Alaska Basic Neuroscience Program, Institute of Arctic Biology, University of Alaska Fairbanks Fairbanks, AK, USA.
Jeanette T MooreDepartment of Chemistry and Biochemistry, Alaska Basic Neuroscience Program, Institute of Arctic Biology, University of Alaska Fairbanks Fairbanks, AK, USA.
Michael B HarrisDepartment of Chemistry and Biochemistry, Alaska Basic Neuroscience Program, Institute of Arctic Biology, University of Alaska Fairbanks Fairbanks, AK, USA.
Kelly L DrewDepartment of Chemistry and Biochemistry, Alaska Basic Neuroscience Program, Institute of Arctic Biology, University of Alaska Fairbanks Fairbanks, AK, USA.
University of Alaska Fairbanks · US

Funding

Rac-1 mediated superoxide signaling in neuronsU54NS041069 · NINDS · UNIVERSITY OF ALASKA FAIRBANKS · PI DUFFY, LAWRENCE K · 2000 to 2011
$14.1M
Targeting Central A1 Adenosine Receptors Induces Hypothermia for StrokeR15NS070779 · NINDS · UNIVERSITY OF ALASKA FAIRBANKS · PI DREW, KELLY L · 2010 to 2014
$949k
NINDS NIH HHS R15 NS070779NINDS NIH HHS U54 NS041069
6 · The paper itself

Abstract

Hibernation is a unique physiological adaptation characterized by periods of torpor that consist of repeated, reversible, and dramatic reductions of body temperature, metabolism, and blood flow. External and internal triggers can induce arousal from torpor in the hibernator. Studies of hibernating animals often require that animals be handled or moved prior to sampling or euthanasia but this movement can induce changes in the hibernation status of the animal. In fact, it has been demonstrated that movement of animals while they are hibernating is sufficient to induce an artificial arousal, which can detrimentally alter experimental findings obtained from animals assumed to be torpid. Therefore, we assessed a method to induce habituation of torpid hibernators to handling and movement to reduce inadvertent arousals. A platform rocker was used to mimic motion experienced during transfer of an animal and changes in respiratory rate (RR) were used to assess responsiveness of torpid Arctic ground squirrels (AGS, Urocitellus parryii). We found that movement alone did not induce a change in RR, however, exposure to handling induced an increase in RR in almost all AGS. This change in RR was markedly reduced with increased exposures, and all AGS exhibited a change in RR ≤ 1 by the end of the study. AGS habituated faster mid-season compared to early in the season, which mirrors other assessments of seasonal variation of torpor depth. However, AGS regained responsiveness when they were not exposed to daily handling. While AGS continued to undergo natural arousals during the study, occurrence of a full arousal was neither necessary for becoming habituated nor detrimental to the time required for habituation. These data suggest that even when torpid, AGS are able to undergo mechanosensory habituation, one of the simplest forms of learning, and provides a reliable way to reduce the sensitivity of torpid animals to handling.

Indexed as

Arctic ground squirrelhabituationhandling and movementhibernationUrocitellus parryii

Identifiers

PMID24847278
PMCPMC4023073
OpenAlexW2024995552

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.