ArticleFrontiers in physiology2014
DNA methylation and temperature stress in an Antarctic polychaete, Spiophanes tcherniai.
Article in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- A protocol of histone modification-based mechanistic study of acupuncture in patients with stable angina pectoris.BMC complementary and alternative medicine · 2015Trial
- Food-dependent activation of one-carbon metabolism during heat shock in Mytilus californianus.The Journal of experimental biology · 2026Article
- Community structure and methylation of microbes in an artificially forced sediment core.Microbiology spectrum · 2026Article
- Thyroid hormone links environmental signals to DNA methylation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Climate change and epigenetic biomarkers in allergic and airway diseases.The Journal of allergy and clinical immunology · 2023Review
- Heatwave resilience of juvenile white sturgeon is associated with epigenetic and transcriptional alterations.Scientific reports · 2023Article
- Third-Generation Sequencing Reveals the Adaptive Role of the Epigenome in Three Deep-Sea Polychaetes.Molecular biology and evolution · 2023Article
- Development of epigenetic biomarkers for the identification of sex and thermal stress in fish using DNA methylation analysis and machine learning procedures.Molecular ecology resources · 2023Article
- ChIP-seq profiling of H3K4me3 and H3K27me3 in an invasive insect,Frontiers in genetics · 2023Article
- DNA Methylation Analysis Reveals Distinct Patterns in Satellite Cell-Derived Myogenic Progenitor Cells of Subjects with Spastic Cerebral Palsy.Journal of personalized medicine · 2022Article
- Review
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- Phylogenomics of the Epigenetic Toolkit Reveals Punctate Retention of Genes across Eukaryotes.Genome biology and evolution · 2020Article
- Epigenetic patterns associated with an ascidian invasion: a comparison of closely related clades in their native and introduced ranges.Scientific reports · 2019Article
- Cytosine Methylation Within Marine Sediment Microbial Communities: Potential Epigenetic Adaptation to the Environment.Frontiers in microbiology · 2019Article
- Coral epigenetic responses to nutrient stress: Histone H2A.X phosphorylation dynamics and DNA methylation in the staghorn coralEcology and evolution · 2018Article
- Epigenetic profiling to environmental stressors in model and non-model organisms: Ecotoxicology perspective.Environmental health and toxicology · 2018Article
- Stress related epigenetic changes may explain opportunistic success in biological invasions in Antipode mussels.Scientific reports · 2018Article
- Epigenetic machine learning: utilizing DNA methylation patterns to predict spastic cerebral palsy.BMC bioinformatics · 2018Article
- Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetic modifications of DNA and histones are a primary mechanism by which gene expression activities may be modified in response to environmental stimuli. Here we characterize patterns of methyl-cytosine composition in the marine polychaete Spiophanes tcherniai from McMurdo Sound, Antarctica. We cultured adult worms at two temperatures, -1.5°C (ambient control) and +4°C (warm treatment), for 4 weeks. We observed a rapid capacity for S. tcherniai organismal respiration rates and underlying catalytic rates of citrate synthase at +4°C to return to control levels in less than 4 weeks. We profiled changes in the methylation states of CpG sites in these treatments using an NGS strategy to computationally reconstruct and quantify methylation status across the genome. In our analysis we recovered 120,000 CpG sites in assembled contigs from both treatments. Of those, we were able to align 28,000 CpG sites in common between the two sample groups. In comparing these aligned sites between treatments, only 3000 (11%) evidenced a change in methylation state, but over 85% of changes involved a gain of a 5-methyl group on a CpG site (net increase in methyation). The ability to score CpG sites as partially methylated among gDNA copies in a sample opens up a new avenue for assessing DNA methylation responses to changing environments. By quantitatively distinguishing a "mixed" population of copies of one CpG site, we can begin to identify dynamic, non-binary, continuous-response reactions in DNA methylation intensity or density that previously may have been overlooked as noise.
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