Evidence map›Paper›PMID 24847274›Full record

ReviewFrontiers in physiology2014

Macrophages in homeostatic immune function.

Jonathan Jantsch, Katrina J Binger, Dominik N Müller, Jens Titze

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
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  11. Review
  12. Review
  13. Article
  14. E3 Ligase FBXW2 Is a New Therapeutic Target in Obesity and Atherosclerosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Article
  15. Review
  16. Article
  17. EffectiveMolecular therapy. Methods & clinical development · 2020
    Article
  18. Cardiac lymphatics in health and disease.Nature reviews. Cardiology · 2019
    Review
  19. Article
  20. Interplay of NaFrontiers in immunology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Jonathan JantschMikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität Erlangen-Nürnberg Erlangen, Germany.
Katrina J BingerExperimental and Clinical Research Center (ECRC), Max-Delbrück Center for Molecular Medicine, Charité Medical Faculty Berlin, Germany.
Dominik N MüllerExperimental and Clinical Research Center (ECRC), Max-Delbrück Center for Molecular Medicine, Charité Medical Faculty Berlin, Germany.
Jens TitzeInterdisciplinary Center for Clinical Research and Department of Nephrology and Hypertension, Friedrich-Alexander-Universität Erlangen-Nürnberg Erlangen, Germany ; Divison of Clinical Pharmacology, Vanderbilt University School of Medicine Nashville, TN, USA.
Charité - Universitätsmedizin Berlin · DEMax Delbrück Center · DEUniversitätsklinikum Erlangen · DEVanderbilt University · US

Funding

Lymphatic Regulation of Skin Electrolyte Metabolism and Blood PressureR01HL118579 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI TITZE, JENS MARC · 2013 to 2017
$1.9M
NHLBI NIH HHS R01 HL118579
6 · The paper itself

Abstract

Macrophages are not only involved in inflammatory and anti-infective processes, but also play an important role in maintaining tissue homeostasis. In this review, we summarize recent evidence investigating the role of macrophages in controlling angiogenesis, metabolism as well as salt and water balance. Particularly, we summarize the importance of macrophage tonicity enhancer binding protein (TonEBP, also termed nuclear factor of activated T-cells 5 [NFAT5]) expression in the regulation of salt and water homeostasis. Further understanding of homeostatic macrophage function may lead to new therapeutic approaches to treat ischemia, hypertension and metabolic disorders.

Indexed as

angiogenesisarteriogenesislipid metabolismmacrophage polarizationNa+ storageperoxisome proliferator activator receptor (PPAR)salttonicity enhance binding protein (TonEBP)/nuclear factor of activated T-cells 5(NFAT5)

Identifiers

PMID24847274
PMCPMC4017126
OpenAlexW2114185978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.