ArticleFrontiers in aging neuroscience2014
Behavioral aging is associated with reduced sensory neuron excitability in Aplysia californica.
Article in Frontiers in aging neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 26 citations in OpenAlex.
- Calorie Restriction Effects on Aging, Learning Performance, and Transcription in Aged Aplysia californica.Genes, brain, and behavior · 2026Article
- Age-related degradation of behavioral and network features ofFrontiers in aging neuroscience · 2026Article
- Experience-mediated transcriptional memory correlates with hypoxia resistance in the nervous system of the sea hareAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Age-related degradation of behavioral and network features ofbioRxiv : the preprint server for biology · 2025Article
- Host response to Aplysia Abyssovirus 1 in nervous system and gill.Developmental and comparative immunology · 2024Article
- Neuromolecular mechanisms related to reflex behaviour inRoyal Society open science · 2024Article
- Improvements in operant memory ofFrontiers in behavioral neuroscience · 2023Article
- An age-related decline in the cholinergic synaptic response may cause the firing pattern in the jaw-closing motor neurons, which resembles the aversive taste response in the feeding behavior of old Aplysia kurodai.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2022Article
- Aplysia Neurons as a Model of Alzheimer's Disease: Shared Genes and Differential Expression.Journal of molecular neuroscience : MN · 2022Article
- Structural aspects of the aging invertebrate brain.Cell and tissue research · 2021Review
- Co-expression analysis identifies neuro-inflammation as a driver of sensory neuron aging in Aplysia californica.PloS one · 2021Article
- Changes in Metabolism and Proteostasis Drive Aging Phenotype inFrontiers in aging neuroscience · 2020Article
- Ocean acidification affects acid-base physiology and behaviour in a model invertebrate, the California sea hare (Royal Society open science · 2019Article
- Altered expression of ionotropic L-Glutamate receptors in aged sensory neurons of Aplysia californica.PloS one · 2019Article
- Whole-transcriptome changes in gene expression accompany aging of sensory neurons in Aplysia californica.BMC genomics · 2018Article
- A comparison of hatchery-rearing in exercise to wild animal physiology and reflex behavior in Aplysia californica.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2018Article
- Phylogenetic analysis of ionotropic L-glutamate receptor genes in the Bilateria, with special notes on Aplysia californica.BMC evolutionary biology · 2017Article
- Effects of aging on the food intake in the feeding behavior of Aplysia kurodai.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2016Article
- Habituation in the Tail Withdrawal Reflex Circuit is Impaired During Aging in Aplysia californica.Frontiers in aging neuroscience · 2016Article
- Decline in the Recovery from Synaptic Depression in Heavier Aplysia Results from Decreased Serotonin-Induced Novel PKC Activation.PloS one · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Invertebrate models have advantages for understanding the basis of behavioral aging due to their simple nervous systems and short lifespans. The potential usefulness of Aplysia californica in aging research is apparent from its long history of neurobiological research, but it has been underexploited in this model use. Aging of simple reflexes at both single sensory neuron and neural circuit levels was studied to connect behavioral aging to neurophysiological aging. The tail withdrawal reflex (TWR), righting reflex, and biting response were measured throughout sexual maturity in 3 cohorts of hatchery-reared animals of known age. Reflex times increased and reflex amplitudes decreased significantly during aging. Aging in sensory neurons of animals with deficits in measures of the TWR and biting response resulted in significantly reduced excitability in old animals compared to their younger siblings. The threshold for firing increased while the number of action potentials in response to depolarizing current injection decreased during aging in sensory neurons, but not in tail motoneurons. Glutamate receptor-activated responses in sensory neurons also decreased with aging. In old tail motoneurons, the amplitude of evoked EPSPs following tail shock decreased, presumably due to reduced sensory neuron excitability during aging. The results were used to develop stages of aging relevant to both hatchery-reared and wild-caught Aplysia. Aplysia is a viable aging model in which the contributions of differential aging of components of neural circuits may be assessed.
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