ArticleFrontiers in behavioral neuroscience2014
Heightened fear in response to a safety cue and extinguished fear cue in a rat model of maternal immune activation.
Article in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
- Neurobiological correlates of behavioral resilience to chronic alcohol and acute stress in male and female rats.Translational psychiatry · 2026Article
- Second-order conditioning of safety in male and female rats.Behavioural brain research · 2026Article
- Translational approaches to the neurobiological study of conditional discrimination and inhibition: Implications for psychiatric disease.Behavioral neuroscience · 2024Review
- Conditioned inhibition of fear and reward in male and female rats.Neurobiology of learning and memory · 2024Article
- Suppressing fear in the presence of a safety cue requires infralimbic cortical signaling to central amygdala.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Encoding of conditioned inhibitors of fear in the infralimbic cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Interaction of stress and alcohol on discriminating fear from safety and reward in male and female rats.Psychopharmacology · 2023Article
- Immune Activation in Pregnant Rats Affects Brain Glucose Consumption, Anxiety-like Behaviour and Recognition Memory in their Male Offspring.Molecular imaging and biology · 2022Article
- The Poly I:C maternal immune stimulation model shows unique patterns of brain metabolism, morphometry, and plasticity in female rats.Frontiers in behavioral neuroscience · 2022Article
- Article
- Sensory filtering disruption caused by poly I:C - Timing of exposure and other experimental considerations.Brain, behavior, & immunity - health · 2020Article
- Differential effects of prior stress on conditioned inhibition of fear and fear extinction.Behavioural brain research · 2020Article
- Know safety, no fear.Neuroscience and biobehavioral reviews · 2020Review
- Sex differences in fear regulation and reward-seeking behaviors in a fear-safety-reward discrimination task.Behavioural brain research · 2019Article
- Adolescent conditioning affects rate of adult fear, safety and reward learning during discriminative conditioning.Scientific reports · 2018Article
- Maternal prenatal depression predicts infant negative affect via maternal inflammatory cytokine levels.Brain, behavior, and immunity · 2018Article
- In utero electroporation induces cell death and alters embryonic microglia morphology and expression signatures in the developing hypothalamus.Journal of neuroinflammation · 2018Article
- Maternal and Early Postnatal Immune Activation Produce Dissociable Effects on Neurotransmission in mPFC-Amygdala Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Developmental disruption of perineuronal nets in the medial prefrontal cortex after maternal immune activation.Scientific reports · 2016Article
- Behavioral alterations in rat offspring following maternal immune activation and ELR-CXC chemokine receptor antagonism during pregnancy: implications for neurodevelopmental psychiatric disorders.Progress in neuro-psychopharmacology & biological psychiatry · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maternal immune activation (MIA) during pregnancy is an environmental risk factor for psychiatric illnesses such as schizophrenia and autism in the offspring. Hence, changes in an array of behaviors, including behavioral flexibility, consistent with altered functioning of cortico-limbic circuits have been reported in rodent models of MIA. Surprisingly, previous studies have not examined the effect of MIA on the extinction of fear conditioning which depends on cortico-limbic circuits. Thus, we tested the effects of treating pregnant Long Evans rats with the viral mimetic polyI:C (gestational day 15; 4 mg/kg; i.v.) on fear conditioning and extinction in the male offspring using two different tasks. In the first experiment, we observed no effect of polyI:C treatment on the acquisition or extinction of a classically conditioned fear memory in a non-discriminative auditory cue paradigm. However, polyI:C-treated offspring did increase contextual freezing during the recall of fear extinction in this non-discriminative paradigm. The second experiment utilized a recently developed task to explicitly test the ability of rats to discriminate among cues signifying fear, reward, and safety; a task that requires behavioral flexibility. To our surprise, polyI:C-treated rats acquired the task in a manner similar to saline-treated rats. However, upon subsequent extinction training, they showed significantly faster extinction of the freezing response to the fear cue. In contrast, during the extinction recall test, polyI:C-treated offspring showed enhanced freezing behavior before and after presentation of the fear cue, suggesting an impairment in their ability to regulate fear behavior. These behavioral results are integrated into the literature suggesting impairments in cortico-limbic brain function in the offspring of rats treated with polyI:C during pregnancy.
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