ArticleFrontiers in systems neuroscience2014
Mesocorticolimbic monoamine correlates of methamphetamine sensitization and motivation.
Article in Frontiers in systems neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Trace amine-associated receptor gene polymorphism increases drug craving in individuals with methamphetamine dependence.PloS one · 2019Trial
- Robust aversive effects of trace amine-associated receptor 1 activation in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Peri-adolescent exposure to (meth)amphetamine in animal models.International review of neurobiology · 2022Review
- Intracranial self-stimulation and concomitant behaviors following systemic methamphetamine administration in Hnrnph1 mutant mice.Psychopharmacology · 2021Article
- Parkin regulates drug-taking behavior in rat model of methamphetamine use disorder.Translational psychiatry · 2021Article
- Hnrnph1 is a novel regulator of alcohol reward.Drug and alcohol dependence · 2021Article
- ERK-Directed Phosphorylation of mGlu5 Gates Methamphetamine Reward and Reinforcement in Mouse.International journal of molecular sciences · 2021Article
- A breeding strategy to identify modifiers of high genetic risk for methamphetamine intake.Genes, brain, and behavior · 2021Article
- The motivational valence of methamphetamine relates inversely to subsequent methamphetamine self-administration in female C57BL/6J mice.Behavioural brain research · 2021Article
- Potential Ago2/miR-3068-5p Cascades in the Nucleus Accumbens Contribute to Methamphetamine-Induced Locomotor Sensitization of Mice.Frontiers in pharmacology · 2021Article
- A Mutation inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- PI3K activation within ventromedial prefrontal cortex regulates the expression of drug-seeking in two rodent species.Addiction biology · 2019Article
- Article
- Depression-like symptoms of withdrawal in a genetic mouse model of binge methamphetamine intake.Genes, brain, and behavior · 2019Article
- Verification of a genetic locus for methamphetamine intake and the impact of morphine.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Prior binge-drinking history promotes the positive affective valence of methamphetamine in mice.Drug and alcohol dependence · 2018Article
- Methamphetamine-alcohol interactions in murine models of sequential and simultaneous oral drug-taking.Drug and alcohol dependence · 2017Article
- Methamphetamine Addiction Vulnerability: The Glutamate, the Bad, and the Ugly.Biological psychiatry · 2017Article
- Behavioral and Neurochemical Phenotyping of Mice Incapable of Homer1a Induction.Frontiers in behavioral neuroscience · 2017Article
- Prefrontal glutamate correlates of methamphetamine sensitization and preference.The European journal of neuroscience · 2016Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Methamphetamine (MA) is a highly addictive psychomotor stimulant, with life-time prevalence rates of abuse ranging from 5-10% world-wide. Yet, a paucity of research exists regarding MA addiction vulnerability/resiliency and neurobiological mediators of the transition to addiction that might occur upon repeated low-dose MA exposure, more characteristic of early drug use. As stimulant-elicited neuroplasticity within dopamine neurons innervating the nucleus accumbens (NAC) and prefrontal cortex (PFC) is theorized as central for addiction-related behavioral anomalies, we used a multi-disciplinary research approach in mice to examine the interactions between sub-toxic MA dosing, motivation for MA and mesocorticolimbic monoamines. Biochemical studies of C57BL/6J (B6) mice revealed short- (1 day), as well as longer-term (21 days), changes in extracellular dopamine, DAT and/or D2 receptors during withdrawal from 10, once daily, 2 mg/kg MA injections. Follow-up biochemical studies conducted in mice selectively bred for high vs. low MA drinking (respectively, MAHDR vs. MALDR mice), provided novel support for anomalies in mesocorticolimbic dopamine as a correlate of genetic vulnerability to high MA intake. Finally, neuropharmacological targeting of NAC dopamine in MA-treated B6 mice demonstrated a bi-directional regulation of MA-induced place-conditioning. These results extend extant literature for MA neurotoxicity by demonstrating that even subchronic exposure to relatively low MA doses are sufficient to elicit relatively long-lasting changes in mesocorticolimbic dopamine and that drug-induced or idiopathic anomalies in mesocorticolimbic dopamine may underpin vulnerability/resiliency to MA addiction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.