ArticleFrontiers in neuroanatomy2014
Super-resolution 2-photon microscopy reveals that the morphology of each dendritic spine correlates with diffusive but not synaptic properties.
Article in Frontiers in neuroanatomy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 50 citations in OpenAlex.
- Contribution of individual excitatory synapses on dendritic spines to electrical signaling.Frontiers in neuroscience · 2025Article
- Electrical properties of dendritic spines.Biophysical journal · 2023Review
- Trafficking proteins show limited differences in mobility across different postsynaptic spines.iScience · 2023Article
- Electrophysiology of Dendritic Spines: Information Processing, Dynamic Compartmentalization, and Synaptic Plasticity.Advances in neurobiology · 2023Article
- Unique properties of dually innervated dendritic spines in pyramidal neurons of the somatosensory cortex uncovered by 3D correlative light and electron microscopy.PLoS biology · 2021Article
- Seeing beyond the limit: A guide to choosing the right super-resolution microscopy technique.The Journal of biological chemistry · 2021Review
- The role of molecular diffusion within dendritic spines in synaptic function.The Journal of general physiology · 2021Review
- Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse.eLife · 2020Article
- Current and future functional imaging techniques for post-traumatic stress disorder.RSC advances · 2019Review
- Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution.Science (New York, N.Y.) · 2019Article
- Probing Single SynapsesFrontiers in synaptic neuroscience · 2019Article
- Trapping in and Escape from Branched Structures of Neuronal Dendrites.Biophysical journal · 2018Article
- Ankyrins: Roles in synaptic biology and pathology.Molecular and cellular neurosciences · 2018Review
- Imaging neuronal structure dynamics using 2-photon super-resolution patterned excitation reconstruction microscopy.Journal of biophotonics · 2018Article
- In Vivo Superresolution Imaging of Neuronal Structure in the Mouse Brain.IEEE transactions on bio-medical engineering · 2018Article
- Sodium Dynamics in Pyramidal Neuron Dendritic Spines: Synaptically Evoked Entry Predominantly through AMPA Receptors and Removal by Diffusion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- βIII Spectrin Is Necessary for Formation of the Constricted Neck of Dendritic Spines and Regulation of Synaptic Activity in Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Social defeat stress induces depression-like behavior and alters spine morphology in the hippocampus of adolescent male C57BL/6 mice.Neurobiology of stress · 2016Article
- Superresolving dendritic spine morphology with STED microscopy under holographic photostimulation.Neurophotonics · 2016Article
- Electrical and Ca(2+) signaling in dendritic spines of substantia nigra dopaminergic neurons.eLife · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The structure of dendritic spines suggests a specialized function in compartmentalizing synaptic signals near active synapses. Indeed, theoretical and experimental analyses indicate that the diffusive resistance of the spine neck is sufficient to effectively compartmentalize some signaling molecules in a spine for the duration of their activated lifetime. Here we describe the application of 2-photon microscopy combined with stimulated emission depletion (STED-2P) to the biophysical study of the relationship between synaptic signals and spine morphology, demonstrating the utility of combining STED-2P with modern optical and electrophysiological techniques. Morphological determinants of fluorescence recovery time were identified and evaluated within the context of a simple compartmental model describing diffusive transfer between spine and dendrite. Correlations between the neck geometry and the amplitude of synaptic potentials and calcium transients evoked by 2-photon glutamate uncaging were also investigated.
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