ArticleSocial cognitive and affective neuroscience2015
Childhood physical abuse predicts stressor-evoked activity within central visceral control regions.
Article in Social cognitive and affective neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Dimensions of early life adversity and cardiometabolic health in adulthood: A systematic review and meta-analysis.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Pooled it
- Towards personalized, brain-based behavioral intervention for transdiagnostic anxiety: Transient neural responses to negative images predict outcomes following a targeted computer-based intervention.Journal of consulting and clinical psychology · 2018Trial
- Noninvasive Suppression of Responses to Threat Using Focused Ultrasonic Waves.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Stressor-Evoked Brain Activity, Cardiovascular Reactivity, and Subclinical Atherosclerosis in Midlife Adults.Journal of the American Heart Association · 2025Article
- Brain and cardiovascular responses to acute stress in remitted and recurrent late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- A preliminary investigation of worry, cortical amyloid burden, and stressor-evoked brain and cardiovascular reactivity in older adults.Journal of affective disorders · 2024Article
- Manual segmentation of the paraventricular nucleus of the hypothalamus and the dorsal and ventral bed nucleus of stria terminalis using multimodal 7 Tesla structural MRI: probabilistic atlases for a stress-control triad.Brain structure & function · 2024Article
- Assessing depression recurrence, cognitive burden, and neurobiological homeostasis in late life: Design and rationale of the REMBRANDT Study.Journal of mood and anxiety disorders · 2024Article
- Stressor-evoked brain activity, cardiovascular reactivity, and subclinical atherosclerosis in midlife adults.medRxiv : the preprint server for health sciences · 2024Article
- Glutamatergic and GABAergic anteroventral BNST projections to PVN CRH neurons regulate maternal separation-induced visceral pain.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Do trait-level emotion regulation strategies moderate associations between retrospective reports of childhood trauma and prospective changes in systemic inflammation?Stress and health : journal of the International Society for the Investigation of Stress · 2023Article
- Evaluation of rosmarinic acid against myocardial infarction in maternally separated rats.Naunyn-Schmiedeberg's archives of pharmacology · 2022Article
- Childhood Threat Is Associated With Lower Resting-State Connectivity Within a Central Visceral Network.Frontiers in psychology · 2022Article
- Promoting brain health through physical activity among adults exposed to early life adversity: Potential mechanisms and theoretical framework.Neuroscience and biobehavioral reviews · 2021Review
- Opposing relationships of childhood threat and deprivation with stria terminalis white matter.Human brain mapping · 2021Article
- Neurobiological mechanisms of early life adversity, blunted stress reactivity and risk for addiction.Neuropharmacology · 2021Review
- Effective connectivity between bed nucleus of the stria terminalis and amygdala: Reproducibility and relation to anxiety.Human brain mapping · 2021Article
- Article
- Interactions between childhood maltreatment and combat exposure trauma on stress-related activity within the cingulate cortex: a pilot study.Military psychology : the official journal of the Division of Military Psychology, American Psychological Association · 2020Article
- Female Mice Exposed to Postnatal Neglect Display Angiotensin II-Dependent Obesity-Induced Hypertension.Journal of the American Heart Association · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Early life experience differentially shapes later stress reactivity, as evidenced by both animal and human studies. However, early experience-related changes in the function of central visceral neural circuits that control stress responses have not been well characterized, particularly in humans. The paraventricular nucleus of the hypothalamus (PVN), bed nucleus of the stria terminalis (BNST), amygdala (Amyg) and subgenual anterior cingulate cortex (sgACC) form a core visceral stress-responsive circuit. The goal of this study is to examine how childhood emotional and physical abuse relates to adulthood stressor-evoked activity within these visceral brain regions. To evoke acute states of mental stress, participants (n = 155) performed functional magnetic resonance imaging (fMRI)-adapted versions of the multi-source interference task (MSIT) and the Stroop task with simultaneous monitoring of mean arterial pressure (MAP) and heart rate. Regression analyses revealed that childhood physical abuse correlated positively with stressor-evoked changes in MAP, and negatively with unbiased, a priori extractions of fMRI blood-oxygen level-dependent signal change values within the sgACC, BNST, PVN and Amyg (n = 138). Abuse-related changes in the function of visceral neural circuits may reflect neurobiological vulnerability to adverse health outcomes conferred by early adversity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.