ArticleSocial cognitive and affective neuroscience2015
Basal forebrain moderates the magnitude of task-dependent amygdala functional connectivity.
Article in Social cognitive and affective neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Task modulated brain connectivity of the amygdala: a meta-analysis of psychophysiological interactions.Brain structure & function · 2017Pooled it
- Molecular, Structural, and Functional Neuroimaging in Major Depression.Advances in experimental medicine and biology · 2026Review
- Article
- Disrupted Choline Clearance and Sustained Acetylcholine ReleaseThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The Construct of Medical and Non-Medical Marijuana-Critical Review.International journal of environmental research and public health · 2022Review
- Correlation Between the Functional Connectivity of Basal Forebrain Subregions and Vigilance Dysfunction in Temporal Lobe Epilepsy With and Without Focal to Bilateral Tonic-Clonic Seizure.Frontiers in psychiatry · 2022Article
- Chronic Ethanol Exposure Potentiates Cholinergic Neurotransmission in the Basolateral Amygdala.Neuroscience · 2021Article
- Task MRI-Based Functional Brain Network of Major Depression.Advances in experimental medicine and biology · 2021Article
- Cholinergic neurotransmission in the basolateral amygdala during cued fear extinction.Neurobiology of stress · 2020Article
- Anterior cingulate cortex differently modulates frontoparietal functional connectivity between resting-state and working memory tasks.Human brain mapping · 2020Article
- Violence and Cannabis Use: A Focused Review of a Forgotten Aspect in the Era of Liberalizing Cannabis.Frontiers in psychiatry · 2020Review
- The basolateral amygdala regulation of complex cognitive behaviours in the five-choice serial reaction time task.Psychopharmacology · 2019Article
- Neuromodulation in circuits of aversive emotional learning.Nature neuroscience · 2019Review
- Compensatory dopaminergic-cholinergic interactions in conflict processing: Evidence from patients with Parkinson's disease.NeuroImage · 2019Article
- The neuropsychopharmacology of cannabis: A review of human imaging studies.Pharmacology & therapeutics · 2019Review
- Cholinergic Signaling Alters Stress-Induced Sensitization of Hippocampal Contextual Learning.Frontiers in neuroscience · 2019Article
- Cholinergic regulation of fear learning and extinction.Journal of neuroscience research · 2017Review
- Amygdala response to explicit sad face stimuli at baseline predicts antidepressant treatment response to scopolamine in major depressive disorder.Psychiatry research. Neuroimaging · 2016Article
- Characterizations of resting-state modulatory interactions in the human brain.Journal of neurophysiology · 2015Article
- Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis.Journal of abnormal psychology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Animal studies reveal that the amygdala promotes attention and emotional memory, in part, by driving activity in downstream target regions including the prefrontal cortex (PFC) and hippocampus. Prior work has demonstrated that the amygdala influences these regions directly through monosynaptic glutamatergic signaling, and indirectly by driving activity of the cholinergic basal forebrain and subsequent downstream acetylcholine release. Yet to date, no work has addressed the functional relevance of the cholinergic basal forebrain in facilitating signaling from the amygdala in humans. We set out to determine how blood oxygen level-dependent signal within the amygdala and cholinergic basal forebrain interact to predict neural responses within downstream targets. Here, we use functional connectivity analyses to demonstrate that the cholinergic basal forebrain moderates increased amygdala connectivity with both the PFC and the hippocampus during the processing of biologically salient stimuli in humans. We further demonstrate that functional variation within the choline transporter gene predicts the magnitude of this modulatory effect. Collectively, our results provide novel evidence for the importance of cholinergic signaling in modulating neural pathways supporting arousal, attention and memory in humans. Further, our results may shed light on prior association studies linking functional variation within the choline transporter gene and diagnoses of major depression and attention-deficit hyperactivity disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.