ArticleNature communications2014
High-fat maternal diet during pregnancy persistently alters the offspring microbiome in a primate model.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 235 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
235 citing papers in PubMed, 3 syntheses or guidelines pooled it, 430 citations in OpenAlex.
- A scientometric visualization analysis of the gut microbiota and gestational diabetes mellitus.Frontiers in microbiology · 2025Pooled it
- The effect of tobacco smoking during pregnancy and breastfeeding on human milk composition-a systematic review.European journal of clinical nutrition · 2021Pooled it
- The role of gut micorbiome in obesity and diabetes.World journal of pediatrics : WJP · 2019Pooled it
- Associations between maternal obesity and offspring gut microbiome in the first year of life.Pediatric obesity · 2022Trial
- The relationship between maternal dietary patterns during pregnancy in women with gestational diabetes mellitus and infant appetitive feeding behaviour at 6 months.Scientific reports · 2020Trial
- Early gut mycobiota and mother-offspring transfer.Microbiome · 2017Trial
- Microbial Legacy: Mycobacterium vaccae ATCC 15483Molecular psychiatry · 2026Article
- Heavy moms, wheezy kids: how maternal obesity harms breathing in offspring.American journal of respiratory cell and molecular biology · 2026Review
- Prenatal training grounds: the developmental origins of chronic immune disease.Journal of translational medicine · 2026Review
- Maternal Low-Fat and High-Fat Diet Decreases Survival and Alters Cytokine Signaling in Neonatal Mice With Staphylococcus epidermidis Sepsis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Reprogramming offspring liver health: maternal indole supplementation as a preventive strategy against MASLD.EBioMedicine · 2026Article
- Programming the Infant Gut: How Maternal and Early Life Nutrition Shape the Infant Microbiome and Long-term Health-A Narrative Review.Molecular nutrition & food research · 2026Review
- Maternal diet-induced hypercholanemia alters gut microbiota and metabolome in adult female Western diet-fed offspring.Experimental biology and medicine (Maywood, N.J.) · 2026Article
- The human mycobiome: a critical yet understudied component of health and disease.Microbiology (Reading, England) · 2025Review
- Maternal obesogenic diet exposure regulates the offspring gut liver axis and fibroinflammatory liver disease.Communications biology · 2025Article
- Parental diet and offspring health: a role for the gut microbiome via epigenetics.Nature reviews. Gastroenterology & hepatology · 2025Review
- Gut Microbiota and Neurodevelopment in Preterm Infants: Mechanistic Insights and Prospects for Clinical Translation.Microorganisms · 2025Review
- Does the Maternal Gut Microbiome Influence the Outcome of Perinatal Asphyxia?Antioxidants (Basel, Switzerland) · 2025Review
- Budding baboon blues: the prenatal diet lands a lasting gut punch.American journal of physiology. Gastrointestinal and liver physiology · 2025Article
- Fermented Apple Juice Reduces the Susceptibility of Offspring Mice to Food Allergy Exacerbated by Maternal High-Fat Diet.Nutrients · 2025Article
175 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
The intestinal microbiome is a unique ecosystem and an essential mediator of metabolism and obesity in mammals. However, studies investigating the impact of the diet on the establishment of the gut microbiome early in life are generally lacking, and most notably so in primate models. Here we report that a high-fat maternal or postnatal diet, but not obesity per se, structures the offspring's intestinal microbiome in Macaca fuscata (Japanese macaque). The resultant microbial dysbiosis is only partially corrected by a low-fat, control diet after weaning. Unexpectedly, early exposure to a high-fat diet diminished the abundance of non-pathogenic Campylobacter in the juvenile gut, suggesting a potential role for dietary fat in shaping commensal microbial communities in primates. Our data challenge the concept of an obesity-causing gut microbiome and rather provide evidence for a contribution of the maternal diet in establishing the microbiota, which in turn affects intestinal maintenance of metabolic health.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.