ArticleBritish journal of pharmacology2014
Orexin A activates hypoglossal motoneurons and enhances genioglossus muscle activity in rats.
Article in British journal of pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Increased Orexin by High Concentration of Sevoflurane Enhances the Suprahyoid Muscle Activity Involves in Gasping-Like Respiration of Mice.FASEB bioAdvances · 2026Article
- Prevalence and Factors Associated with Rapid Eye Movement-Related Obstructive Sleep Apnea in Patients with Narcolepsy.Nature and science of sleep · 2025Article
- Article
- Obstructive sleep apnea.Handbook of clinical neurology · 2022Review
- Whole-Brain Monosynaptic Inputs to Hypoglossal Motor Neurons in Mice.Neuroscience bulletin · 2020Article
- Prevalence of Rapid Eye Movement-related Obstructive Sleep Apnea in Adult Narcolepsy.Internal medicine (Tokyo, Japan) · 2019Article
- Neuroanatomical Basis of State-Dependent Activity of Upper Airway Muscles.Frontiers in neurology · 2018Review
- Orexin and Central Modulation of Cardiovascular and Respiratory Function.Current topics in behavioral neurosciences · 2017Review
- Early improvement in obstructive sleep apnea and increase in orexin levels after bariatric surgery in adolescents and young adults.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2017Observational
- Neural Control of the Upper Airway: Respiratory and State-Dependent Mechanisms.Comprehensive Physiology · 2016Review
- The effect of leptin replacement on sleep-disordered breathing in the leptin-deficient ob/ob mouse.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeOrexins have been demonstrated to play important roles in many physiological processes. However, it is not known how orexin A affects the activity of the hypoglossal motoneuron (HMN) and genioglossus (GG) muscle. EXPERIMENTAL APPROACH: GG muscle electromyograms (GG-EMG) were recorded in anaesthetized adult rats after orexin A or orexin receptor antagonists were applied to the hypoglossal nucleus, and in adult rats in which orexin neurons were lesioned with the neurotoxin orexin-saporin (orexin-SAP). HMN membrane potential and firing were recorded from neonatal rat brain slices using whole-cell patch clamp after an infusion of orexin A or orexin receptor antagonists. KEY
resultsUnilateral micro-injection of orexin A (50, 100 or 200 μM) into the hypoglossal nucleus significantly enhanced ipsilateral GG activity in adult rats. Orexin A (4, 20, 100 or 500 nM) depolarized the resting membrane potential and increased the firing rate of HMNs in a dose-dependent manner in the medullary slices of neonatal rats. Both SB 334867, a specific OX1 receptor antagonist and TCS OX2 29, a specific OX2 receptor antagonist not only blocked the depolarized membrane potential and the increased firing rate of HMNs by orexin A in the neonatal model but also attenuated GG-EMG in the adult model. A significant decrease in GG-EMG was observed in adult orexin neuron-lesioned rats compared with sham animals. CONCLUSION AND IMPLICATIONS: Orexin A activates OX1 and OX2 receptors within the hypoglossal motor pool and promotes GG activity, indicating that orexin A is involved in controlling respiratory motor activity.
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