ArticleThe Journal of clinical endocrinology and metabolism2014
Lipid concentrations and couple fecundity: the LIFE study.
Article in The Journal of clinical endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- The Association between Circulating Lipids and Female Infertility Risk: A Univariable and Multivariable Mendelian Randomization Analysis.Nutrients · 2023Pooled it
- The Association of Female and Male Preconception Dyslipidemia With Live Birth in Couples Seeking Fertility Treatment.The Journal of clinical endocrinology and metabolism · 2024Trial
- Adiposity is associated with anovulation independent of serum free testosterone: A prospective cohort study.Paediatric and perinatal epidemiology · 2021Trial
- Pilot randomized trial of short-term changes in inflammation and lipid levels during and after aspirin and pravastatin therapy.Reproductive health · 2019Trial
- Preconception maternal lipoprotein levels in relation to fecundability.Human reproduction (Oxford, England) · 2017Trial
- Couple-level dyslipidemia and embryological and cumulative pregnancy outcomes in IVF/ICSI cycles: a single-center retrospective cohort study.Frontiers in endocrinology · 2026Article
- Dyslipidemia and female reproductive failures: perspectives on lipid metabolism and endometrial immune dysregulation.Seminars in immunopathology · 2025Review
- Association between atherogenic index of plasma and infertility: a cross-sectional study based on U.S. women.Lipids in health and disease · 2025Article
- Delineating lipidomic landscapes in human and mouse ovaries: Spatial signatures and chemically-induced alterations via MALDI mass spectrometry imaging: Spatial ovarian lipidomics.Environment international · 2024Article
- Non-high-density to high-density lipoprotein cholesterol ratio and its association with infertility in U.S. women: a cross-sectional study.Frontiers in endocrinology · 2024Article
- Proteomic Analysis Identifies Distinct Protein Patterns for High Ovulation inAnimals : an open access journal from MDPI · 2023Article
- Maternal hypercholesterolemia would increase the incidence of embryo aneuploidy in couples with recurrent implantation failure.European journal of medical research · 2023Article
- The current situation and future directions for the study on time-to-pregnancy: a scoping review.Reproductive health · 2022Article
- Metabolic health status and fecundability in a Singapore preconception cohort study.American journal of obstetrics and gynecology · 2022Article
- Implications of High-Density Cholesterol Metabolism for Oocyte Biology and Female Fertility.Frontiers in cell and developmental biology · 2022Review
- Serum Lipid Levels and Treatment Outcomes in Women Undergoing Assisted Reproduction: A Retrospective Cohort Study.Frontiers in endocrinology · 2021Article
- Maternal hypercholesterolemia programs dyslipidemia in adult male mouse progeny.Reproduction (Cambridge, England) · 2020Article
- Gestational hypercholesterolemia alters fetal hepatic lipid metabolism and microRNA expression in Apo-E-deficient mice.American journal of physiology. Endocrinology and metabolism · 2019Article
- Preconception serum lipids and lipophilic micronutrient levels are associated with live birth rates after IVF.Reproductive biomedicine online · 2019Article
- Metabolic Syndrome and Male Fertility.The world journal of men's health · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
contextA role of lipids in human fecundity is hypothesized as cholesterol is the main substrate for steroid synthesis and has also been shown to affect the hormonal milieu and steroidogenesis in both men and women.
objectiveThe objective of the study was to evaluate the association between male and female serum lipid concentrations and time to pregnancy (TTP). DESIGN/
settingA population-based prospective cohort study recruiting couples from 16 counties in Michigan and Texas (2005-2009) using sampling frameworks allowing for identification of couples planning pregnancy in the near future.
participantsFive hundred one couples desiring pregnancy and discontinuing contraception were followed up for 12 months or until a human chorionic gonadotropin pregnancy was detected. MAIN OUTCOME AND MEASURES: Fecundability odds ratios (FORs) and 95% confidence intervals (CIs) were estimated after adjusting for age, body mass index, race, and education in relationship to female, male, and joint couple lipid concentrations.
resultsSerum free cholesterol levels were higher on average among male and female partners of couples who did not became pregnant during the study follow-up (female, P = .04; male, P = .009), and levels in female partners were associated with significantly longer TTP in models based on both individual and couples concentrations (individual models: FOR 0.98, 95% CI 0.97, 0.99; couple models: FOR 0.98, 95% CI 0.97, 0.99). Male free cholesterol concentrations were associated with TTP only in the couple-based models (FOR 0.98, 95% CI 0.97, 0.99). Sensitivity analyses suggested that the observed associations are unlikely to be explained by potential unmeasured confounding such as diet.
conclusionsOur results suggest that serum free cholesterol concentrations in both men and women have an effect on TTP, highlighting the importance of cholesterol and lipid homeostasis for male and female fecundity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.