ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2014
SAA drives proinflammatory heterotypic macrophage differentiation in the lung via CSF-1R-dependent signaling.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 54 citations in OpenAlex.
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- Early-life house dust mite aeroallergen exposure augments cigarette smoke-induced myeloid inflammation and emphysema in mice.Respiratory research · 2024Article
- Pentraxin 3 Inhibits Complement-driven Macrophage Activation to Restrain Granuloma Formation in Sarcoidosis.American journal of respiratory and critical care medicine · 2022Article
- Analytical performance of a canine ELISA monocyte chemoattractant protein-1 assay for use in cats and evaluation of circulating levels in normal weight and obese cats.Acta veterinaria Scandinavica · 2022Article
- Targeting the human βRespirology (Carlton, Vic.) · 2022Article
- Maternal siRNA silencing of placental SAA2 mitigates preterm birth following intrauterine inflammation.Frontiers in immunology · 2022Article
- Review
- Serum Amyloid A1 (SAA1) Revisited: Restricted Leukocyte-Activating Properties of Homogeneous SAA1.Frontiers in immunology · 2020Article
- Expression of SAA1, SAA2 and SAA4 genes in human primary monocytes and monocyte-derived macrophages.PloS one · 2019Article
- Serum Amyloid A Contributes to Chronic Apical Periodontitis via TLR2 and TLR4.Journal of dental research · 2019Article
- Serum Amyloid A Stimulates Vascular and Renal Dysfunction in Apolipoprotein E-Deficient Mice Fed a Normal Chow Diet.Frontiers in immunology · 2019Article
- Building and Regenerating the Lung Cell by Cell.Physiological reviews · 2019Review
- Serum Amyloid A1 Is an Epithelial Prorestitutive Factor.The American journal of pathology · 2018Article
- The IL-33 Receptor ST2 Regulates Pulmonary Inflammation and Fibrosis to Bleomycin.Frontiers in immunology · 2018Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
Serum amyloid A (SAA) is expressed locally in chronic inflammatory conditions such as chronic obstructive pulmonary disease (COPD), where macrophages that do not accord with the classic M1/M2 paradigm also accumulate. In this study, the role of SAA in regulating macrophage differentiation was investigated in vitro using human blood monocytes from healthy subjects and patients with COPD and in vivo using an airway SAA challenge model in BALB/c mice. Differentiation of human monocytes with SAA stimulated the proinflammatory monokines IL-6 and IL-1β concurrently with the M2 markers CD163 and IL-10. Furthermore, SAA-differentiated macrophages stimulated with lipopolysaccharide (LPS) expressed markedly higher levels of IL-6 and IL-1β. The ALX/FPR2 antagonist WRW4 reduced IL-6 and IL-1β expression but did not significantly inhibit phagocytic and efferocytic activity. In vivo, SAA administration induced the development of a CD11c(high)CD11b(high) macrophage population that generated higher levels of IL-6, IL-1β, and G-CSF following ex vivo LPS challenge. Blocking CSF-1R signaling effectively reduced the number of CD11c(high)CD11b(high) macrophages by 71% and also markedly inhibited neutrophilic inflammation by 80%. In conclusion, our findings suggest that SAA can promote a distinct CD11c(high)CD11b(high) macrophage phenotype, and targeting this population may provide a novel approach to treating chronic inflammatory conditions associated with persistent SAA expression.
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Registered trials
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