ArticleCell stress & chaperones2014
Group 1 LEA proteins contribute to the desiccation and freeze tolerance of Artemia franciscana embryos during diapause.
Article in Cell stress & chaperones, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- The unorthodox aquaporin-12L ortholog is essential for oogenesis in the crustacean Artemia franciscana.Bioscience reports · 2026Article
- Biomolecular condensates-Prerequisites for anhydrobiosis?Protein science : a publication of the Protein Society · 2025Review
- Functional and Conformational Plasticity of an Animal Group 1 LEA Protein.Biomolecules · 2022Article
- LEA motifs promote desiccation tolerance in vivo.BMC biology · 2021Article
- The genome of the extremophile Artemia provides insight into strategies to cope with extreme environments.BMC genomics · 2021Article
- Article
- Overexpression of Medicago sativa LEA4-4 can improve the salt, drought, and oxidation resistance of transgenic Arabidopsis.PloS one · 2020Article
- Mechanisms of Desiccation Tolerance: Themes and Variations in Brine Shrimp, Roundworms, and Tardigrades.Frontiers in physiology · 2020Review
- The synthesis of diapause-specific molecular chaperones in embryos of Artemia franciscana is determined by the quantity and location of heat shock factor 1 (Hsf1).Cell stress & chaperones · 2019Article
- Does water stress promote the proteome-wide adjustment of intrinsically disordered proteins in plants?Cell stress & chaperones · 2018Article
- Article
- Stress tolerance in diapausing embryos of Artemia franciscana is dependent on heat shock factor 1 (Hsf1).PloS one · 2018Article
- LEA proteins are involved in cyst desiccation resistance and other abiotic stresses in Azotobacter vinelandii.Cell stress & chaperones · 2017Article
- ArHsp40, a type 1 J-domain protein, is developmentally regulated and stress inducible in post-diapause Artemia franciscana.Cell stress & chaperones · 2016Article
- Mechanisms of animal diapause: recent developments from nematodes, crustaceans, insects, and fish.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Review
- Stress tolerance during diapause and quiescence of the brine shrimp, Artemia.Cell stress & chaperones · 2016Review
- Article
- Study of model systems to test the potential function of Artemia group 1 late embryogenesis abundant (LEA) proteins.Cell stress & chaperones · 2016Article
- The C. elegans dauer larva as a paradigm to study metabolic suppression and desiccation tolerance.Planta · 2015Review
- Molecular approaches for improving desiccation tolerance: insights from the brine shrimp Artemia franciscana.Planta · 2015Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Water loss either by desiccation or freezing causes multiple forms of cellular damage. The encysted embryos (cysts) of the crustacean Artemia franciscana have several molecular mechanisms to enable anhydrobiosis-life without water-during diapause. To better understand how cysts survive reduced hydration, group 1 late embryogenesis abundant (LEA) proteins, hydrophilic unstructured proteins that accumulate in the stress-tolerant cysts of A. franciscana, were knocked down using RNA interference (RNAi). Embryos lacking group 1 LEA proteins showed significantly lower survival than control embryos after desiccation and freezing, or freezing alone, demonstrating a role for group 1 LEA proteins in A. franciscana tolerance of low water conditions. In contrast, regardless of group 1 LEA protein presence, cysts responded similarly to hydrogen peroxide (H2O2) exposure, indicating little to no function for these proteins in diapause termination. This is the first in vivo study of group 1 LEA proteins in an animal and it contributes to the fundamental understanding of these proteins. Knowing how LEA proteins protect A. franciscana cysts from desiccation and freezing may have applied significance in aquaculture, where Artemia is an important feed source, and in the cryopreservation of cells for therapeutic applications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.