ArticleChemical senses2014
Salty taste deficits in CALHM1 knockout mice.
Article in Chemical senses, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Receptors and signaling for sour and salty: the ionic taste qualities.Chemical senses · 2025Review
- Fat preference deficits and experience-induced recovery in global taste-deficient Trpm5 and Calhm1 knockout mice.Physiology & behavior · 2022Article
- Taste Receptor Signaling.Handbook of experimental pharmacology · 2022Article
- On the molecular nature of large-pore channels.Journal of molecular biology · 2021Review
- Recent Advances in Understanding Peripheral Taste Decoding I: 2010 to 2020.Endocrinology and metabolism (Seoul, Korea) · 2021Review
- Taste transduction and channel synapses in taste buds.Pflugers Archiv : European journal of physiology · 2021Review
- CALHM1/CALHM3 channel is intrinsically sorted to the basolateral membrane of epithelial cells including taste cells.Scientific reports · 2019Article
- Greater reductions in fat preferences in CALHM1 than CD36 knockout mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Cyclophosphamide-Induced Disruptions to Appetitive Qualities and Detection Thresholds of NaCl: Comparison of Single-Dose and Dose Fractionation Effects.Chemical senses · 2018Article
- Development of Full Sweet, Umami, and Bitter Taste Responsiveness Requires Regulator of G protein Signaling-21 (RGS21).Chemical senses · 2018Article
- CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes.Neuron · 2018Article
- Calhm2 governs astrocytic ATP releasing in the development of depression-like behaviors.Molecular psychiatry · 2018Article
- ATP Release Channels.International journal of molecular sciences · 2018Review
- A novel quantified bitterness evaluation model for traditional Chinese herbs based on an animal ethology principle.Acta pharmaceutica Sinica. B · 2018Article
- Taste buds: cells, signals and synapses.Nature reviews. Neuroscience · 2017Review
- Phosphorus Taste Involves T1R2 and T1R3.Chemical senses · 2017Article
- Measurement of Behavioral Taste Responses in Mice: Two-Bottle Preference, Lickometer, and Conditioned Taste-Aversion Tests.Current protocols in mouse biology · 2016Article
- Normal Taste Acceptance and Preference of PANX1 Knockout Mice.Chemical senses · 2015Article
- Mice Lacking Pannexin 1 Release ATP and Respond Normally to All Taste Qualities.Chemical senses · 2015Article
- Honing in on the ATP Release Channel in Taste Cells.Chemical senses · 2015Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Genetic ablation of calcium homeostasis modulator 1 (CALHM1), which releases adenosine triphosphate from Type 2 taste cells, severely compromises the behavioral and electrophysiological responses to tastes detected by G protein-coupled receptors, such as sweet and bitter. However, the contribution of CALHM1 to salty taste perception is less clear. Here, we evaluated several salty taste-related phenotypes of CALHM1 knockout (KO) mice and their wild-type (WT) controls: 1) In a conditioned aversion test, CALHM1 WT and KO mice had similar NaCl avoidance thresholds. 2) In two-bottle choice tests, CALHM1 WT mice showed the classic inverted U-shaped NaCl concentration-preference function but CALHM1 KO mice had a blunted peak response. 3) In brief-access tests, CALHM1 KO mice showed less avoidance than did WT mice of high concentrations of NaCl, KCl, NH(4)Cl, and sodium lactate (NaLac). Amiloride further ameliorated the NaCl avoidance of CALHM1 KO mice, so that lick rates to a mixture of 1000 mM NaCl + 10 µM amiloride were statistically indistinguishable from those to water. 4) Relative to WT mice, CALHM1 KO mice had reduced chorda tympani nerve activity elicited by oral application of NaCl, NaLac, and sucrose but normal responses to HCl and NH(4)Cl. Chorda tympani responses to NaCl and NaLac were amiloride sensitive in WT but not KO mice. These results reinforce others demonstrating that multiple transduction pathways make complex, concentration-dependent contributions to salty taste perception. One of these pathways depends on CALHM1 to detect hypertonic NaCl in the mouth and signal the aversive taste of concentrated salt.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.