ArticleBritish journal of pharmacology2014
Pharmacological bronchodilation is partially mediated by reduced airway wall stiffness.
Article in British journal of pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Effect of Extracellular Matrix Stiffness on Candesartan Efficacy in Anti-Fibrosis and Antioxidation.Antioxidants (Basel, Switzerland) · 2023Article
- Tissue traction microscopy to quantify muscle contraction within precision-cut lung slices.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Mechanopharmacology and Synergistic Relaxation of Airway Smooth Muscle.Journal of engineering and science in medical diagnostics and therapy · 2019Article
- The Strain on Airway Smooth Muscle During a Deep Inspiration to Total Lung Capacity.Journal of engineering and science in medical diagnostics and therapy · 2019Article
- Transition From Phasic to Tonic Contractility in Airway Smooth Muscle After Birth: An Experimental and Computational Modeling Study.Journal of engineering and science in medical diagnostics and therapy · 2019Article
- Mechanical Abnormalities of the Airway Wall in Adult Mice After Intrauterine Growth Restriction.Frontiers in physiology · 2019Article
- Cellular Biomechanics in Drug Screening and Evaluation: Mechanopharmacology.Trends in pharmacological sciences · 2016Review
- Can breathing-like pressure oscillations reverse or prevent narrowing of small intact airways?Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Pharmacology of novel treatments for COPD: are fixed dose combination LABA/LAMA synergistic?European clinical respiratory journal · 2015Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeIn asthmatic patients, airflow limitation is at least partly reversed by administration of pharmacological bronchodilators, typically β2 -adrenoceptor agonists. In addition to receptor-mediated bronchodilation, the dynamic mechanical environment of the lung itself can reverse bronchoconstriction. We have now explored the possibility that bronchodilators exert a synergistic effect with oscillatory loads by virtue of reducing airway wall stiffness, and therefore, enhancing the bronchodilatory response to breathing manoeuvres. EXPERIMENTAL APPROACH: Whole porcine bronchial segments in vitro were contracted to carbachol and relaxed to the non-specific β-adrenoceptor agonist, isoprenaline, under static conditions or during simulated breathing manoeuvres. KEY
resultsThe bronchodilatory response to isoprenaline was greater during breathing manoeuvres compared with the response under static conditions. As the bronchodilatory response to breathing manoeuvres is dependent upon airway smooth muscle (ASM) strain, and therefore, airway wall stiffness, our findings are likely to be explained by the effect of isoprenaline on reducing airway wall stiffness, which increased ASM strain, producing greater bronchodilation. CONCLUSIONS AND IMPLICATIONS: A contribution of reduced airway stiffness and increased ASM strain to the bronchodilator action of isoprenaline is shown, suggesting that oscillatory loads act synergistically with pharmacologically mediated bronchodilation. The implications for the treatment of asthma are that reducing airway wall stiffness represents a potential target for novel pharmacological agents.
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