ArticleVirulence2014
Reduced virulence of melanized Cryptococcus neoformans in Galleria mellonella.
Article in Virulence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Ubiquitin degradation of the Ribonuclease H2 subunit B Rnh2B regulates the virulence ofVirulence · 2025Article
- Impact of egg incubation on hemocyte recruitment and susceptibility ofFrontiers in microbiology · 2025Article
- Investigation of the influence of pH and temperature on melanization and survival under oxidative stress in Cryptococcus neoformans.Archives of microbiology · 2024Article
- Melanin depletion affects Aspergillus flavus conidial surface proteins, architecture, and virulence.Applied microbiology and biotechnology · 2024Article
- Review
- Reciprocal modulation of ammonia and melanin production has implications for cryptococcal virulence.Nature communications · 2023Article
- Galleria mellonella immune melanization is fungicidal during infection.Communications biology · 2022Article
- Cryptococcus spp. and Cryptococcosis: focusing on the infection in Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Review
- Article
- Review
- Fungal immunity and pathogenesis in mammals versus the invertebrate model organism Galleria mellonella.Pathogens and disease · 2021Review
- Dexamethasone and Methylprednisolone Promote Cell Proliferation, Capsule Enlargement, andFrontiers in fungal biology · 2021Article
- Rearing and Maintenance ofJournal of fungi (Basel, Switzerland) · 2020Review
- Article
- The enigmatic role of fungal annexins: the case of Cryptococcus neoformans.Microbiology (Reading, England) · 2019Article
- A Small Aromatic Compound Has Antifungal Properties and Potential Anti-Inflammatory Effects against Intestinal Inflammation.International journal of molecular sciences · 2019Article
- Recent Advances in the Use ofJournal of fungi (Basel, Switzerland) · 2018Review
- Exophiala dermatitidis isolates from various sources: using alternative invertebrate host organisms (Caenorhabditis elegans and Galleria mellonella) to determine virulence.Scientific reports · 2018Article
- CapC, a Novel Autotransporter and Virulence Factor of Campylobacter jejuni.Applied and environmental microbiology · 2018Article
- Characterizing the Mechanisms of Nonopsonic Uptake of Cryptococci by Macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Fungal melanins are important in the virulence of many pathogenic fungi. In this study, we examined the role of melanin in the interaction between Cryptococcus neoformans and the invertebrate host, Galleria mellonella. C. neoformans was able to melanize in the presence of G. mellonella homogenate, indicating the presence of melanin substrates. Melanization was confirmed by the recovery of acid-resistant particles that were recognized by anti-melanin antibodies. In addition, we tested the effect of fungal melanization on virulence. Surprisingly, G. mellonella larvae infected with melanized fungal cells lived longer than those infected with non-melanized fungi. When the cellular immune response of G. mellonella to melanized and non-melanized cells was compared, inflammatory nodules were observed in both groups. However the response was stronger in larvae infected with melanized cells. These results suggest that fungal melanin activates the immune response of G. mellonella, thereby resulting in the decreased virulence observed with melanized cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.