ArticleLa Radiologia medica2014
Apparent diffusion coefficient value of hepatic fibrosis and inflammation in children with chronic hepatitis.
Article in La Radiologia medica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Comparison of diffusion-weighted imaging and MR elastography in staging liver fibrosis: a meta-analysis.Abdominal radiology (New York) · 2021Pooled it
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- Pooled it
- Staging liver fibrosis with various diffusion-weighted magnetic resonance imaging models.World journal of gastroenterology · 2024Article
- Predictors of Long-Term Rebleeding Risk in Cirrhotic Patients Undergoing Esophagogastric Devascularization and Splenectomy: Impact of Portal Vein Thrombosis and Hemoglobin Levels.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Correction to: Comparison of diffusion‑weighted imaging and MR elastography in staging liver fibrosis: a meta‑analysis.Abdominal radiology (New York) · 2023Article
- Sequential HBV treatment with tenofovir alafenamide for patients with chronic hepatitis B: week 96 results from a real-world, multicenter cohort study.Hepatology international · 2022Article
- Diffusion tensor imaging of renal cortex in lupus nephritis.Japanese journal of radiology · 2021Article
- Portal vein thrombosis associated with high 14-day and 6-week rebleeding in patients after oesophageal variceal band ligation: a retrospective, multicentre, nested case-control study.Hepatology international · 2021Article
- Diffusion tensor imaging of the spleen in prediction and grading of esophageal varices in cirrhotic children with portal hypertension.Japanese journal of radiology · 2021Article
- Spinach consumption and nonalcoholic fatty liver disease among adults: a case-control study.BMC gastroenterology · 2021Article
- Hsa-circRNA-103809 Promotes Hepatocellular Carcinoma Development via MicroRNA-1270/PLAG1 Like Zinc Finger 2 Axis.Digestive diseases and sciences · 2021Article
- Prevalence of nonalcoholic fatty liver disease in mental disorder inpatients in China: an observational study.Hepatology international · 2021Observational
- Obesity interacts with hyperuricemia on the severity of non-alcoholic fatty liver disease.BMC gastroenterology · 2021Article
- Dual-Energy Computed Tomography of the Liver: Uses in Clinical Practices and Applications.Diagnostics (Basel, Switzerland) · 2021Review
- The role of diffusion tensor imaging of the liver in children with autoimmune hepatitis.Polish journal of radiology · 2021Article
- Association between liver diffusion-weighted imaging apparent diffusion coefficient values and other measures of liver disease in pediatric autoimmune liver disease patients.Abdominal radiology (New York) · 2021Article
- Assessment of Diffusion Tensor Imaging Parameters of Hepatic Parenchyma for Differentiation of Biliary Atresia from Alagille Syndrome.Korean journal of radiology · 2020Article
- Association of arterial stiffness with the histological severity of nonalcoholic fatty liver disease.Hepatology international · 2020Article
- Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats.World journal of gastroenterology · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study was done to prospectively evaluate the usefulness of apparent diffusion coefficient (ADC) in the diagnosis and grading of hepatic fibrosis and inflammation in children with chronic hepatitis. MATERIALS AND
methodsInstitutional Review Board approval was obtained. This prospective study was carried out on 50 children with chronic hepatitis (mean age 8.3 ± 3.2 years; 33 boys and 17 girls) and 20 age- and sex-matched healthy control children. The children underwent diffusion-weighted magnetic resonance imaging of the liver. The ADC value of the liver was calculated. The hepatic fibrosis stages (F1-F6) and necroinflammatory activity grades (A1-A4) were calculated. The ADC values of different stages of hepatic fibrosis and grades of necroinflammatory activity were calculated.
resultsThe mean ADC value of the liver parenchyma was 1.53 ± 0.17 × 10(-3) mm(2)/s in children with chronic hepatitis and 1.74 ± 0.16 × 10(-3) mm(2)/s in controls. The ADC value was significantly lower in children with hepatic fibrosis compared to controls (p = 0.001). There was a significant difference (p = 0.001) in ADC between mild (F1-F3) and advanced (F4-F6) stages of fibrosis. There was a significant difference (p = 0.004) in ADC between mild (A1-A2) and advanced (A3-A4) grades of necroinflammation. The cut-off ADC values used to differentiate mild from advanced fibrosis and necroinflammation were 1.62 and 1.64 mm(2)/s with an area under the curve of 0.898 and 0.807, respectively. The ADC value negatively correlated with stages of hepatic fibrosis (r = -0.799, p = 0.001) and necroinflammatory activity grade (r = -0.468, p = 0.001).
conclusionsWe conclude that ADC value is an effective noninvasive parameter for the diagnosis and grading of hepatic fibrosis and inflammation in children with chronic hepatitis.
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