ArticleJournal of neural transmission (Vienna, Austria : 1996)2014
A reappraisal of Fe(III) adsorption by melanin.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Ferroptosis as a Pathogenic Mechanism and Therapeutic Target in Autoimmune and Inflammatory Skin Diseases.Clinical reviews in allergy & immunology · 2026Review
- Phenotypic Switching of B16F10 Melanoma Cells as a Stress Adaptation Response to Fe3O4/Salicylic Acid Nanoparticle Therapy.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Changes in cytoplasmic and extracellular neuromelanin in human substantia nigra with normal aging.European journal of histochemistry : EJH · 2021Article
- Functions of fungal melanin beyond virulence.Fungal biology reviews · 2017Article
- Transplanted Neural Stem Cells: Playing a Neuroprotective Role by Ceruloplasmin in the Substantia Nigra of PD Model Rats?Oxidative medicine and cellular longevity · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adsorptive capacity of melanin for Fe(III) was investigated. Iron is involved in promoting the formation of reactive oxygen species which has consequently been associated with Parkinson's disease. Neuromelanin has been suggested to act as an iron scavenger and, therefore, determining the capacity of melanin to adsorb iron is relevant. Although a few reports have quantified the binding capacity, the current research examined the effect of solution pH on adsorption as well as considering physiologically relevant matrices. In addition, desorption is described for the first time. Our results indicated that adsorption over an acidic pH range was relatively constant and was not significantly affected by the presence of protein or lipid. This paper, therefore, goes beyond published reports by investigating a broader range of factors. It also highlights the importance of melanin in the brain through its homeostatic regulation of Fe(III), through the desorption profile of melanin, a novel result.
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Registered trials
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