ArticleThe Journal of comparative neurology2014
Identification of bladder and colon afferents in the nodose ganglia of male rats.
Article in The Journal of comparative neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- A Non-spinal Neural Circuit for Transmitting Information of Bladder Conditions.Neuroscience bulletin · 2026Article
- Involvement of the hypothalamus-raphe magnus-spinal defecation center axis in stress-induced defecation in rats.Communications biology · 2026Article
- From bladder to brain: How you know when it's time to go.Current opinion in neurobiology · 2025Review
- Corticotropin-releasing factor type 1 receptors in the rat nodose ganglion are involved in the transduction of stress-induced visceral sensory signals to the brain.Journal of neuroendocrinology · 2025Article
- Article
- Genetic tools that target mechanoreceptors produce reliable labeling of bladder afferents and altered mechanosensation.American journal of physiology. Renal physiology · 2025Article
- Visceral Pain in Preterm Infants with Necrotizing Enterocolitis: Underlying Mechanisms and Implications for Treatment.Paediatric drugs · 2025Review
- Tissue damage-induced axon injury-associated responses in sensory neurons: requirements, prevention, and potential role in persistent post-surgical pain.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- From dysbiosis to precision therapy: decoding the gut-bladder axis in bladder carcinogenesis.Frontiers in oncology · 2025Review
- Neuromodulation for the treatment of sexual dysfunction: an opportunity for the field.Current opinion in biomedical engineering · 2024Article
- Vagal afferent responses to cystometry in rat models of urinary bladder irritation: c-fos immunohistochemistry study.International urology and nephrology · 2024Article
- The parasympathetic and sensory innervation of the proximal and distal colon in male mice.Frontiers in neuroanatomy · 2024Article
- The influence of Nav1.9 channels on intestinal hyperpathia and dysmotility.Channels (Austin, Tex.) · 2023Review
- Partners in Pain: New Insights into The Role of CGRP Signaling in Cross-Organ Sensitization.The Journal of pharmacology and experimental therapeutics · 2023Article
- Analysis of the spinal and vagal afferent innervation of the mouse colon using neuronal retrograde tracers.Cell and tissue research · 2023Article
- The effect of vagotomy on c-fos expression in the reticular formation areas following cystometry in cyclophosphamide-induced cystitis in rats.American journal of clinical and experimental urology · 2023Article
- Analysis of the distribution of vagal afferent projections from different peripheral organs to the nucleus of the solitary tract in rats.The Journal of comparative neurology · 2022Article
- Spinal cord injury-mediated changes in electrophysiological properties of rat gastric nodose ganglion neurons.Experimental neurology · 2022Article
- Upregulation of P2X3 receptors in primary afferent pathways involves in colon-to-bladder cross-sensitization in rats.Frontiers in physiology · 2022Article
- Functional anatomy of the vagus system - Emphasis on the somato-visceral interface.Autonomic neuroscience : basic & clinical · 2021Article
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Authors and funding
5 authors.
Funding
Abstract
The sensory neurons innervating the urinary bladder and distal colon project to similar regions of the central nervous system and often are affected simultaneously by various diseases and disorders, including spinal cord injury. Anatomical and physiological commonalities between the two organs involve the participation of shared spinally derived pathways, allowing mechanisms of communication between the bladder and colon. Prior electrophysiological data from our laboratory suggest that the bladder also may receive sensory innervation from a nonspinal source through the vagus nerve, which innervates the distal colon as well. The present study therefore aimed to determine whether anatomical evidence exists for vagal innervation of the male rat urinary bladder and to assess whether those vagal afferents also innervate the colon. Additionally, the relative contribution to bladder and colon sensory innervation of spinal and vagal sources was determined. By using lipophilic tracers, neurons that innervated the bladder and colon in both the nodose ganglia (NG) and L6/S1 and L1/L2 dorsal root ganglia (DRG) were quantified. Some single vagal and spinal neurons provided dual innervation to both organs. The proportions of NG afferents labeled from the bladder did not differ from spinal afferents labeled from the bladder when considering the collective population of total neurons from either group. Our results demonstrate evidence for vagal innervation of the bladder and colon and suggest that dichotomizing vagal afferents may provide a neural mechanism for cross-talk between the organs.
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