ArticleJournal of biosciences2014
Modelling the transition from simple to complex Ca²⁺ oscillations in pancreatic acinar cells.
Article in Journal of biosciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 57 citations in OpenAlex.
- Computational Model of Complex Calcium Dynamics: Store Operated CaCell biochemistry and biophysics · 2025Article
- Model of Calcium Dynamics RegulatingActa biotheoretica · 2024Article
- 2D dynamic analysis of the disturbances in the calcium neuronal model and its implications in neurodegenerative disease.Cognitive neurodynamics · 2023Article
- Study of disorders in regulatory spatiotemporal neurodynamics of calcium and nitric oxide.Cognitive neurodynamics · 2023Article
- Cellular nitric oxide synthesis is affected by disorders in the interdependentJournal of biological physics · 2023Article
- Mechanistic insights of neuronal calcium and IPEuropean biophysics journal : EBJ · 2023Article
- Effect of disturbances in neuronal calcium and IP3 dynamics on β-amyloid production and degradation.Cognitive neurodynamics · 2023Article
- To study the effect of ER flux with buffer on the neuronal calcium.European physical journal plus · 2023Article
- Article
- The Effect of Gap Junctional Coupling on the Spatiotemporal Patterns of Ca2+ Signals and the Harmonization of Ca2+-Related Cellular Responses.PLoS computational biology · 2016Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A mathematical model is proposed which systematically investigates complex calcium oscillations in pancreatic acinar cells. This model is based on calcium-induced calcium release via inositol trisphosphate receptors (IPR) and ryanodine receptors (RyR) and includes calcium modulation of inositol (1,4,5) trisphosphate (IP3) levels through feedback regulation of degradation and production. In our model, the apical and the basal regions are separated by a region containing mitochondria, which is capable of restricting Ca2+ responses to the apical region. We were able to reproduce the observed oscillatory patterns, from baseline spikes to sinusoidal oscillations. The model predicts that calcium-dependent production and degradation of IP3 is a key mechanism for complex calcium oscillations in pancreatic acinar cells. A partial bifurcation analysis is performed which explores the dynamic behaviour of the model in both apical and basal regions.
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