ArticlePsychoneuroendocrinology2014
Glucocorticoid receptors in the nucleus of the solitary tract (NTS) decrease endocrine and behavioral stress responses.
Article in Psychoneuroendocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Inter-Organ Communication Networks in Systemic Physiology: Glucocorticoid Receptor α as a Central Integrator of Homeostasis.International journal of molecular sciences · 2026Review
- Nutritional Management of Schizophrenia: Gut-Brain Axis Mechanisms and Dietary Interventions.Molecular neurobiology · 2026Review
- Transcutaneous auricular vagus nerve stimulation inhibits mental stress-induced cortisol release-Potential implications for inflammatory conditions.Physiological reports · 2025Article
- Olfactory and trigeminal routes of HSV-1 CNS infection with regional microglial heterogeneity.Journal of virology · 2024Article
- Hindbrain Adrenergic/Noradrenergic Control of Integrated Endocrine and Autonomic Stress Responses.Endocrinology · 2023Review
- Defensive responses: behaviour, the brain and the body.Nature reviews. Neuroscience · 2023Review
- Chronic administration of glucocorticoid receptor ligands increases anxiety-like behavior and selectively increase serotonin transporters in the ventral hippocampus.Brain research · 2023Article
- Brain nuclear receptors and cardiovascular function.Cell & bioscience · 2023Review
- Long-term sevoflurane exposure relieves stress-enhanced fear learning and anxiety in PTSD mice.Translational neuroscience · 2023Article
- Overtraining Syndrome as a Complex Systems Phenomenon.Frontiers in network physiology · 2021Review
- Corticosterone inhibits vagal afferent glutamate release in the nucleus of the solitary tract via retrograde endocannabinoid signaling.American journal of physiology. Cell physiology · 2020Article
- Brain mechanisms of HPA axis regulation: neurocircuitry and feedback in context Richard Kvetnansky lecture.Stress (Amsterdam, Netherlands) · 2020Review
- Infralimbic cortical glutamate output is necessary for the neural and behavioral consequences of chronic stress.Neurobiology of stress · 2020Article
- Shape Deformation in the Brainstem of Medication-Naïve Female Patients with Major Depressive Disorder.Psychiatry investigation · 2020Article
- Article
- Acute stress response to a cognitive task in patients with major depressive disorder: potential metabolic and proinflammatory biomarkers.Metabolic brain disease · 2019Article
- Probabilistic Template of the Lateral Parabrachial Nucleus, Medial Parabrachial Nucleus, Vestibular Nuclei Complex, and Medullary Viscero-Sensory-Motor Nuclei Complex in Living Humans From 7 Tesla MRI.Frontiers in neuroscience · 2019Article
- Regulation of Hypothalamo-Pituitary-Adrenocortical Responses to Stressors by the Nucleus of the Solitary Tract/Dorsal Vagal Complex.Cellular and molecular neurobiology · 2018Review
- Corticolimbic regulation of cardiovascular responses to stress.Physiology & behavior · 2017Review
- Ascending mechanisms of stress integration: Implications for brainstem regulation of neuroendocrine and behavioral stress responses.Neuroscience and biobehavioral reviews · 2017Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Stress activates the hypothalamo-pituitary-adrenal (HPA) axis, leading to adrenocortical secretion of glucocorticoids. The magnitude and duration of the HPA axis response is mediated in large part by the glucocorticoid receptor (GR). The nucleus of the solitary tract (NTS) abundantly expresses the GR and is a key brain region for processing autonomic and endocrine stress responses. This study tests the hypothesis that GR within the NTS plays an important role in inhibiting stress-induced endocrine and behavioral responses. Cohorts of rats received bilateral micropellet (30 μg) implantations of crystalline corticosterone, mifepristone (a GR antagonist) or cholesterol (control) directed into the region of the NTS, and were subsequently subjected to either acute psychogenic (restraint) stress or chronic variable stress (CVS). We found that NTS GR antagonism increased acute stress-induced corticosterone levels, whereas GR activation within the NTS attenuated this response. Following CVS, basal and 15 min post-restraint plasma corticosterone levels were increased by NTS GR antagonism, which was associated with an increase in Fos immunoreactivity within the PVN. Using the elevated plus maze (EPM) and forced swim test (FST), we assessed the effect of NTS GR inhibition on anxiety- and depression-like behaviors, respectively. GR inhibition within the NTS decreased open arm exploratory behavior in the EPM and increased immobility in the FST relative to controls. Together, the findings reveal a novel role of NTS GR signaling for inhibiting both endocrine and behavioral responses to stress.
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