Evidence map›Paper›PMID 24844847›Full record

SynthesisPloS one2014

Internet-delivered psychological treatments for mood and anxiety disorders: a systematic review of their efficacy, safety, and cost-effectiveness.

Filip K Arnberg, Steven J Linton, Monica Hultcrantz, Emelie Heintz, Ulf Jonsson

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04989842 (Studies on the Effectiveness and Equivalence of an Internet-based Virtual Classroom Intervention for Psychosomatic Aftercare According to the Hannover Curriculum), which is not on this map. Cited by 153 papers, 24 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed, 24 pooled it
32.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04989842 nacompletednot on this mapstarted 2017, after this paper: background citation

Studies on the Effectiveness and Equivalence of an Internet-based Virtual Classroom Intervention for Psychosomatic Aftercare According to the Hannover Curriculum

TypeinterventionalSponsorDr. Becker Hospital GroupRan2017 to 2021Enrolled6,023ConditionsPsychosomatic Disorder, Mental DisorderArmsCurriculum Hannover
3 · Its place in the literature

Who cites it

153 citing papers in PubMed, 24 syntheses or guidelines pooled it, 351 citations in OpenAlex.

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  4. Digital Patient Experience: Umbrella Systematic Review.Journal of medical Internet research · 2022
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  6. Digital interventions in mental health: evidence syntheses and economic modelling.Health technology assessment (Winchester, England) · 2022
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93 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Filip K ArnbergDepartment of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden.
Steven J LintonCenter for Health and Medical Psychology, Department of Law, Psychology, and Social Work, Örebro University, Örebro, Sweden.
Monica HultcrantzSwedish Council on Health Technology Assessment, Stockholm, Sweden.
Emelie HeintzSwedish Council on Health Technology Assessment, Stockholm, Sweden; Center for Medical Technology Assessment (CMT), Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Ulf JonssonSwedish Council on Health Technology Assessment, Stockholm, Sweden; Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Swedish Council on Technology Assessment in Health Care · SEÖrebro University · SEUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGreater access to evidence-based psychological treatments is needed. This review aimed to evaluate whether internet-delivered psychological treatments for mood and anxiety disorders are efficacious, noninferior to established treatments, safe, and cost-effective for children, adolescents and adults.

methodsWe searched the literature for studies published until March 2013. Randomized controlled trials (RCTs) were considered for the assessment of short-term efficacy and safety and were pooled in meta-analyses. Other designs were also considered for long-term effect and cost-effectiveness. Comparisons against established treatments were evaluated for noninferiority. Two reviewers independently assessed the relevant studies for risk of bias. The quality of the evidence was graded using an international grading system.

resultsA total of 52 relevant RCTs were identified whereof 12 were excluded due to high risk of bias. Five cost-effectiveness studies were identified and three were excluded due to high risk of bias. The included trials mainly evaluated internet-delivered cognitive behavioral therapy (I-CBT) against a waiting list in adult volunteers and 88% were conducted in Sweden or Australia. One trial involved children. For adults, the quality of evidence was graded as moderate for the short-term efficacy of I-CBT vs. waiting list for mild/moderate depression (d = 0.83; 95% CI 0.59, 1.07) and social phobia (d = 0.85; 95% CI 0.66, 1.05), and moderate for no efficacy of internet-delivered attention bias modification vs. sham treatment for social phobia (d =  -0.04; 95% CI -0.24, 0.35). The quality of evidence was graded as low/very low for other disorders, interventions, children/adolescents, noninferiority, adverse events, and cost-effectiveness.

conclusionsI-CBT is a viable treatment option for adults with depression and some anxiety disorders who request this treatment modality. Important questions remain before broad implementation can be supported. Future research would benefit from prioritizing adapting treatments to children/adolescents and using noninferiority designs with established forms of treatment.

Indexed as

InternetAdolescentAdultAnxiety DisordersChildChild, PreschoolCognitive Behavioral TherapyCost-Benefit AnalysisHumansMood DisordersPsychotherapyPublication BiasRandomized Controlled Trials as TopicTime FactorsTreatment Outcome

Identifiers

PMID24844847
PMCPMC4028301
OpenAlexW2113690422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.