ArticleJournal of thrombosis and thrombolysis2015
Solvent/detergent plasma: pharmaceutical characteristics and clinical experience.
Article in Journal of thrombosis and thrombolysis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 37 citations in OpenAlex.
- Dried Plasma for Major Trauma: Past, Present, and Future.Life (Basel, Switzerland) · 2024Review
- Reported transfusion-related acute lung injury associated with solvent/detergent plasma - A case series.Transfusion · 2022Article
- Article
- Prevalence and Phylogenetic Analysis of Parvovirus (B19V) among Blood Donors with Different Nationalities Residing in Qatar.Viruses · 2021Article
- Rare congenital bleeding disorders.Annals of translational medicine · 2018Review
- Health Technology Assessment of pathogen reduction technologies applied to plasma for clinical use.Blood transfusion = Trasfusione del sangue · 2016Review
- Is solvent/detergent plasma better than standard fresh-frozen plasma? A systematic review and an expert consensus document.Blood transfusion = Trasfusione del sangue · 2016Review
- Convalescent plasma: new evidence for an old therapeutic tool?Blood transfusion = Trasfusione del sangue · 2016Review
- Human Parvovirus B19 and blood product safety: a tale of twenty years of improvements.Blood transfusion = Trasfusione del sangue · 2015Review
- Treatment of Ebola virus infection with antibodies from reconvalescent donors.Emerging infectious diseases · 2015Article
- Use of Fresh-frozen Plasma in Newborn Infants.Newborn (Clarksville, Md.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The solvent/detergent treatment is an established virus inactivation technology that has been industrially applied for manufacturing plasma derived medicinal products for almost 30 years. Solvent/detergent plasma is a pharmaceutical product with standardised content of clotting factors, devoid of antibodies implicated in transfusion-related acute lung injury pathogenesis, and with a very high level of decontamination from transfusion-transmissible infectious agents. Many clinical studies have confirmed its safety and efficacy in the setting of congenital as well as acquired bleeding disorders. This narrative review will focus on the pharmaceutical characteristics of solvent/detergent plasma and the clinical experience with this blood product.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.