ArticleGenesis (New York, N.Y. : 2000)2014
A series of Cre-ER(T2) drivers for manipulation of the skeletal muscle lineage.
Article in Genesis (New York, N.Y. : 2000), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- PAX3-SIX2 muscle stem cell heterogeneity drives muscle-specific repair dynamics diversification.Science advances · 2026Article
- ANXA11 suppression restores muscular function in the mdx mouse model of Duchenne muscular dystrophy (DMD).Nature communications · 2026Article
- Loss of TMEM65 in mice causes mitochondrial disease mediated by mitochondrial CaNature communications · 2026Article
- Stage- and tissue-specific gene editing using 4-OHT-inducible Cas9 in whole organism.The Journal of cell biology · 2026Article
- Targeting the melanocytes of the inner ear: A comparison of different CreER lines.Developmental biology · 2026Article
- Neuromuscular junction transcriptome analysis of spinal and bulbar muscular atrophy mice implicates sarcomere gene expression and calcium flux dysregulation in disease pathogenesis.Human molecular genetics · 2025Article
- Direct specification of lymphatic endothelium from mesenchymal progenitors.Nature cardiovascular research · 2025Article
- Gene Manipulation of Muscle Phenotype.Advances in experimental medicine and biology · 2025Review
- Systematic Transmission Electron Microscopy-Based Identification and 3D Reconstruction of Cellular Degradation Machinery.Advanced biology · 2023Article
- Influence of vitamin D on sarcopenia pathophysiology: A longitudinal study in humans and basic research in knockout mice.Journal of cachexia, sarcopenia and muscle · 2022Article
- Biophysical matrix cues from the regenerating niche direct muscle stem cell fate in engineered microenvironments.Biomaterials · 2021Article
- Myf6/MRF4 is a myogenic niche regulator required for the maintenance of the muscle stem cell pool.EMBO reports · 2020Article
- CORP: Using transgenic mice to study skeletal muscle physiology.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Review
- Possible application of muscle specific conditional mouse-derived induced pluripotent stem cells for muscle research.Biochemistry and biophysics reports · 2020Article
- Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion under Stress.Cell stem cell · 2019Article
- Loss of SMYD1 Results in Perinatal Lethality via Selective Defects within Myotonic Muscle Descendants.Diseases (Basel, Switzerland) · 2018Article
- Generation and Analysis of Striated Muscle Selective LINC Complex Protein Mutant Mice.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Reporter-Based Isolation of Developmental Myogenic Progenitors.Frontiers in physiology · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We report the generation of five mouse strains with the tamoxifen-inducible Cre (Cre-ER(T) (2) ; CE) gene cassette knocked into the endogenous loci of Pax3, Myod1, Myog, Myf6, and Myl1, collectively as a resource for the skeletal muscle research community. We characterized these CE strains using the Cre reporter mice, R26R(L) (acZ) , during embryogenesis and show that they direct tightly controlled tamoxifen-inducible reporter expression within the expected cell lineage determined by each myogenic gene. We also examined a few selected adult skeletal muscle groups for tamoxifen-inducible reporter expression. None of these new CE alleles direct reporter expression in the cardiac muscle. All these alleles follow the same knock-in strategy by replacing the first exon of each gene with the CE cassette, rendering them null alleles of the endogenous gene. Advantages and disadvantages of this design are discussed. Although we describe potential immediate use of these strains, their utility likely extends beyond foreseeable questions in skeletal muscle biology.
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