Trial reportPloS one2014
Effects of an Internet-based cognitive behavioral therapy (iCBT) program in Manga format on improving subthreshold depressive symptoms among healthy workers: a randomized controlled trial.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 46 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of a Web Application That Supports Behavior Change in Work Related Stress - a Randomized Controlled Trial
Moodbuster, a Guided Self-help Intervention for Prevention of Depression in Primary Care
Who cites it
46 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Optimizing Workplace Digital Mental Health Interventions: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- Long-Term Effect of Cognitive Behavioral Therapy in Managing Subclinical Depression: A Systematic Review and Meta-Analysis.Depression and anxiety · 2025Pooled it
- Skill Enactment and Knowledge Acquisition in Digital Cognitive Behavioral Therapy for Depression and Anxiety: Systematic Review of Randomized Controlled Trials.Journal of medical Internet research · 2023Pooled it
- Trends in Effectiveness of Organizational eHealth Interventions in Addressing Employee Mental Health: Systematic Review and Meta-analysis.Journal of medical Internet research · 2022Pooled it
- Technological State of the Art of Electronic Mental Health Interventions for Major Depressive Disorder: Systematic Literature Review.Journal of medical Internet research · 2020Pooled it
- eHealth interventions for the prevention of depression and anxiety in the general population: a systematic review and meta-analysis.BMC psychiatry · 2017Pooled it
- Improving Employee Well-Being and Effectiveness: Systematic Review and Meta-Analysis of Web-Based Psychological Interventions Delivered in the Workplace.Journal of medical Internet research · 2017Pooled it
- Effectiveness of eHealth interventions for reducing mental health conditions in employees: A systematic review and meta-analysis.PloS one · 2017Pooled it
- Internet-based cognitive behavioural therapy for subthreshold depression: a systematic review and meta-analysis.BMC psychiatry · 2016Pooled it
- Assessing the Efficacy of the INTELLECT Cognitive Behavioral Therapy Mobile App for Anxiety and Depressive Symptoms Among At-Risk Japanese Employees: Randomized Controlled Trial.JMIR mHealth and uHealth · 2025Trial
- Efficacy of Internet-Based Cognitive Behavioral Therapy for Subthreshold Depression Among Older Adults in Institutional Long-Term Care Settings: Pragmatic Randomized Controlled Trial.Journal of medical Internet research · 2024Trial
- Effect of smartphone-based stress management programs on depression and anxiety of hospital nurses in Vietnam: a three-arm randomized controlled trial.Scientific reports · 2021Trial
- Effects of Smartphone-Based Stress Management on Improving Work Engagement Among Nurses in Vietnam: Secondary Analysis of a Three-Arm Randomized Controlled Trial.Journal of medical Internet research · 2021Trial
- Differences in the Effect of Internet-Based Cognitive Behavioral Therapy for Improving Nonclinical Depressive Symptoms Among Workers by Time Preference: Randomized Controlled Trial.Journal of medical Internet research · 2018Trial
- A smartphone application for treating depressive symptoms: study protocol for a randomised controlled trial.BMC psychiatry · 2018Trial
- Can we learn to manage stress? A randomized controlled trial carried out on university students.PloS one · 2018Trial
- Use of a decision aid did not decrease decisional conflict in patients with carpal tunnel syndrome.BMC musculoskeletal disorders · 2017Trial
- Behavioral activation for late adolescents with subthreshold depression: a randomized controlled trial.European child & adolescent psychiatry · 2016Trial
- Trial
- Salutogenic Principles in Workplace Health Promotion Interventions: A Scoping Review.Journal of prevention (2022) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purpose of this study was to develop a new Internet-based computerized cognitive behavior therapy (iCBT) program in Manga format, the Japanese cartoon, for workers and to examine the effects of the iCBT program on improving subthreshold depression using a randomized controlled trial (RCT) design among workers employed in private companies in Japan.
methodAll workers in a company (n = 290) and all workers in three departments (n = 1,500) at the headquarters of another large company were recruited by an invitation e-mail. Participants who fulfilled the inclusion criteria were randomly allocated to intervention or control groups (N = 381 for each group). A six-week, six-lesson iCBT program using Manga (Japanese comic) story was developed. The program included several CBT skills: self-monitoring, cognitive restructuring, assertiveness, problem solving, and relaxation. The intervention group studied the iCBT program at a frequency of one lesson per week. Depression (Beck Depression Inventory II; BDI-II) was assessed as a primary outcome at baseline, and three- and six-month follow-ups for both intervention and control groups were performed.
resultsThe iCBT program showed a significant intervention effect on BDI-II (t = -1.99, p<0.05) with small effect sizes (Cohen's d: -0.16, 95% Confidence Interval: -0.32 to 0.00, at six-month follow-up).
conclusionsThe present study first demonstrated that a computerized cognitive behavior therapy delivered via the Internet was effective in improving depression in the general working population. It seems critical to improve program involvement of participants in order to enhance the effect size of an iCBT program.
trial registrationUMIN Clinical Trials Registry UMIN000006210.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.