ArticleTissue barriers2014
The role of angiomotin phosphorylation in the Hippo pathway during preimplantation mouse development.
Article in Tissue barriers, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 65 citations in OpenAlex.
- Multi-omics and low-input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos.FEBS open bio · 2026Article
- Patient-derived AMOTL1 mutations lead to defective cell migration and tissue development.Bioscience reports · 2026Article
- Research progress on regulatory mechanisms of mucosal barriers and their applications in allergic diseases.Frontiers in immunology · 2026Review
- The asymmetric expression of HSPA2 in blastomeres governs the first embryonic cell-fate decision.eLife · 2025Article
- Role of angiomotin family members in human diseases (Review).Experimental and therapeutic medicine · 2024Review
- Determining the minimal amount of DMSO necessary to stabilize the Angiomotin lipid binding domain.Indiana University journal of undergraduate research · 2024Article
- Pharmacological inhibition of CLK2 activates YAP by promoting alternative splicing of AMOTL2.eLife · 2023Article
- The role of Hippo pathway in ovarian development.Frontiers in physiology · 2023Review
- Overview of junctional complexes during mammalian early embryonic development.Frontiers in endocrinology · 2023Review
- The role of polarization and early heterogeneities in the mammalian first cell fate decision.Current topics in developmental biology · 2023Review
- Suppression of YAP safeguards human naïve pluripotency.Development (Cambridge, England) · 2022Article
- Trophectoderm formation: regulation of morphogenesis and gene expressions by RHO, ROCK, cell polarity, and HIPPO signaling.Reproduction (Cambridge, England) · 2022Review
- Molecular regulation of trophoblast stem cell self-renewal and giant cell differentiation by the Hippo components YAP and LATS1.Stem cell research & therapy · 2022Article
- Self-Sustained Regulation or Self-Perpetuating Dysregulation: ROS-dependent HIF-YAP-Notch Signaling as a Double-Edged Sword on Stem Cell Physiology and Tumorigenesis.Frontiers in cell and developmental biology · 2022Review
- "Biomechanical Signaling in Oocytes and Parthenogenetic Cells".Frontiers in cell and developmental biology · 2021Review
- Hippo Signaling in Embryogenesis and Development.Trends in biochemical sciences · 2021Review
- Establishment of a relationship between blastomere geometry and YAP localisation during compaction.Development (Cambridge, England) · 2020Article
- A tale of two cell-fates: role of the Hippo signaling pathway and transcription factors in early lineage formation in mouse preimplantation embryos.Molecular human reproduction · 2020Review
- Review
- Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Hippo signaling pathway regulates a number of cellular events, including the control of cell fates in preimplantation mouse embryos. The inner and outer cells of the embryo show high and low levels of Hippo signaling, respectively. This position-dependent Hippo signaling promotes the specification of distinct cell fates. In a recent paper, we identified the molecular mechanism that controls Hippo signaling in preimplantation embryos. The junction-associated scaffold protein Angiomotin (Amot) plays a key role in this mechanism. At the adherens junctions of the inner cells, Amot activates the Hippo pathway by recruiting and activating the protein kinase large tumor suppressor (Lats). In contrast, Amot at the apical membrane of the outer cells suppresses Hippo signaling by interacting with F-actin. The phosphorylation of Amot inhibits its interaction with F-actin and activates Hippo signaling. We propose that Amot acts as a molecular switch for the Hippo pathway and links F-actin with Lats activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.