Evidence map›Paper›PMID 24843541›Full record

ReviewJournal of diabetes investigation2012

Significantly increased risk of cancer in diabetes mellitus patients: A meta-analysis of epidemiological evidence in Asians and non-Asians.

Hiroshi Noto, Tetsuro Tsujimoto, Mitsuhiko Noda

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of diabetes investigation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
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  6. Review
  7. Article
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  13. Article
  14. Prevalence of diabetes in Japanese patients with cancer.Journal of diabetes investigation · 2020
    Article
  15. Review
  16. Article
  17. Article
  18. Association Between Metformin and Sulfonylurea Monotherapies and Cancer Incidence: A Real-World Cohort Study in Shanghai, China.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2019
    Article
  19. Review
  20. Does metformin usage improve survival in head and neck squamous cell carcinoma? A population-based study.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hiroshi NotoDepartment of Diabetes and Metabolic Medicine, Center Hospital ; Department of Diabetes Research, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Tetsuro TsujimotoDepartment of Diabetes and Metabolic Medicine, Center Hospital ; Department of Diabetes Research, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Mitsuhiko NodaDepartment of Diabetes and Metabolic Medicine, Center Hospital ; Department of Diabetes Research, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledAims/Introduction:  Emerging evidence from observational studies suggests that diabetes mellitus affects the cancer risk. However, whether there are differences in the magnitude of the influence of diabetes among ethnic groups is unknown. MATERIALS AND

methodsWe searched MEDLINE and the Cochrane Library for pertinent articles that had been published as of 4 April 2011, and included them in a meta-analysis of the risk of all-cancer mortality and incidence in diabetic subjects.

resultsA total of 33 studies were included in the meta-analysis, and they provided 156,132 diabetic subjects for the mortality analysis and 993,884 for the incidence analysis. Cancer mortality was approximately 3%, and cancer incidence was approximately 8%. The pooled adjusted risk ratio (RR) of all-cancer mortality was significantly higher than for non-diabetic people (RR 1.32 [CI 1.20-1.45] for Asians; RR 1.16 [CI 1.01-1.34] for non-Asians). Diabetes was also associated with an increased RR of incidence across all cancer types (RR 1.23 [CI 1.09-1.39] for Asians; RR 1.15 [CI 0.94-1.43] for non-Asians). The RR of incident cancer for Asian men was significantly higher than for non-Asian men (P = 0.021).

conclusionsDiabetes is associated with a higher risk for incident cancer in Asian men than in non-Asian men. In light of the exploding global epidemic of diabetes, particularly in Asia, a modest increase in the cancer risk will translate into a substantial socioeconomic burden. Our current findings underscore the need for clinical attention and better-designed studies of the complex interactions between diabetes and cancer. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2011.00183.x, 2012).

Indexed as

CancerDiabetesMeta‐analysis

Identifiers

PMID24843541
PMCPMC4014928

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.