Evidence map›Paper›PMID 24843374›Full record

ArticlePsychiatry investigation2014

Association of the PPAR-γ Gene with Altered Glucose Levels and Psychosis Profile in Schizophrenia Patients Exposed to Antipsychotics.

Yun-Ru Liu, Tsung-Ming Hu, Tsuo-Hung Lan, Hsien-Jane Chiu, Yung-Han Chang, Shuo-Fei Chen, Yen-Hsin Yu, Cheng-Chung Chen, El-Wui Loh

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
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Article in Psychiatry investigation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 1 country.

Yun-Ru LiuOffice of Research and Development, Taipei Medical University, Taipei, Taiwan.
Tsung-Ming HuYuli Veterans Hospital, Yuli Township, Hualian County, Taiwan.
Tsuo-Hung LanFaculty of Medicine, National Yang Ming University, Taipei, Taiwan. ; Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan. ; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan.
Hsien-Jane ChiuFaculty of Medicine, National Yang Ming University, Taipei, Taiwan. ; Chung Hwa University of Medical Technology, Tainan, Taiwan. ; Department of Health Care and Social Work, Yu Da University of Science and Technology, Chao-chiao Township, Miaoli County, Taiwan.
Yung-Han ChangInstitute of Public Health and Department of Public Health, National Yang Ming University, Taipei, Taiwan.
Shuo-Fei ChenDepartment of Health Care and Social Work, Yu Da University of Science and Technology, Chao-chiao Township, Miaoli County, Taiwan. ; Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan.
Yen-Hsin YuInstitute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
Cheng-Chung ChenKaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung, Taiwan.
El-Wui LohKaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung, Taiwan.
Kaohsiung Municipal Kai-Syuan Psychiatric Hospital · TWChung Hwa University of Medical Technology · TWInstitute of Molecular Biology, Academia Sinica · TWNational Taiwan University · TWNational Yang Ming Chiao Tung University · TWTaichung Veterans General Hospital · TWTaipei Medical University · TWYuli Veterans Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMetabolic abnormalities, e.g., diabetes, are common among schizophrenia patients. Peroxisome proliferator activated receptor-γ (PPAR-γ) regulates glucose/lipid metabolisms, and schizophrenia like syndrome may be induced by actions involving retinoid X receptor-α/PPAR-γ heterodimers. We examined a possible role of the PPAR-γ gene in metabolic traits and psychosis profile in schizophrenia patients exposed to antipsychotics.

methodsSingle nucleotide polymorphisms (SNPs) of the PPAR-γ gene and a serial of metabolic traits were determined in 394 schizophrenia patients, among which 372 were rated with Positive and Negative Syndrome Scale (PANSS).

resultsSNP-10, -12, -18, -19, -20 and -26 were associated with glycated hemoglobin (HbA1c) whereas SNP-18, -19, -20 and -26 were associated with fasting plasma glucose (FPG). While SNP-23 was associated with triglycerides, no associations were identified between the other SNPs and lipids. Further haplotype analysis demonstrated an association between the PPAR-γ gene and psychosis profile.

conclusionOur study suggests a role of the PPAR-γ gene in altered glucose levels and psychosis profile in schizophrenia patients exposed to antipsychotics. Although the Pro12Ala at exon B has been concerned an essential variant in the development of obesity, the lack of association of the variant with metabolic traits in this study should not be treated as impossibility or a proof of error because other factors, e.g., genes regulated by PPAR-γ, may have complicated the development of metabolic abnormalities. Whether the PPAR-γ gene modifies the risk of metabolic abnormalities or psychosis, or causes metabolic abnormalities that lead to psychosis, remains to be examined.

Indexed as

GlucosePPAR-γ genePsychosisSchizophrenia

Identifiers

PMID24843374
PMCPMC4023093
OpenAlexW1978387455

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.