ArticleProceedings of the National Academy of Sciences of the United States of America2014
Subthreshold resonance properties contribute to the efficient coding of auditory spatial cues.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 81 citations in OpenAlex.
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- Cellular and synaptic specializations for sub-millisecond precision in the mammalian auditory brainstem.Frontiers in cellular neuroscience · 2025Review
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- Structure and dynamics that specialize neurons for high-frequency coincidence detection in the barn owl nucleus laminaris.Biological cybernetics · 2023Article
- Modulation of potassium conductances optimizes fidelity of auditory information.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Interaural time difference sensitivity under binaural cochlear implant stimulation persists at high pulse rates up to 900 pps.Scientific reports · 2023Article
- Efficient information coding and degeneracy in the nervous system.Current opinion in neurobiology · 2022Review
- The voltage and spiking responses of subthreshold resonant neurons to structured and fluctuating inputs: persistence and loss of resonance and variability.Biological cybernetics · 2022Review
- Sensitivity to Envelope Interaural Time Differences: Modeling Auditory Modulation Filtering.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Predicting the Influence of Axon Myelination on Sound Localization Precision Using a Spiking Neural Network Model of Auditory Brainstem.Frontiers in neuroscience · 2022Article
- Binaural Processing Deficits Due to Synaptopathy and Myelin Defects.Frontiers in neural circuits · 2022Article
- Auditory Brainstem Models: Adapting Cochlear Nuclei Improve Spatial Encoding by the Medial Superior Olive in Reverberation.Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- Ambient noise exposure induces long-term adaptations in adult brainstem neurons.Scientific reports · 2021Article
- Modulation of Neuronal Potassium Channels During Auditory Processing.Frontiers in neuroscience · 2021Review
- Active membrane conductances and morphology of a collision detection neuron broaden its impedance profile and improve discrimination of input synchrony.Journal of neurophysiology · 2019Article
- Frequency-dependent responses of neuronal models to oscillatory inputs in current versus voltage clamp.Biological cybernetics · 2019Article
- Membrane potential resonance in non-oscillatory neurons interacts with synaptic connectivity to produce network oscillations.Journal of computational neuroscience · 2019Article
- Soma-axon coupling configurations that enhance neuronal coincidence detection.PLoS computational biology · 2019Article
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Neurons in the medial superior olive (MSO) and lateral superior olive (LSO) of the auditory brainstem code for sound-source location in the horizontal plane, extracting interaural time differences (ITDs) from the stimulus fine structure and interaural level differences (ILDs) from the stimulus envelope. Here, we demonstrate a postsynaptic gradient in temporal processing properties across the presumed tonotopic axis; neurons in the MSO and the low-frequency limb of the LSO exhibit fast intrinsic electrical resonances and low input impedances, consistent with their processing of ITDs in the temporal fine structure. Neurons in the high-frequency limb of the LSO show low-pass electrical properties, indicating they are better suited to extracting information from the slower, modulated envelopes of sounds. Using a modeling approach, we assess ITD and ILD sensitivity of the neural filters to natural sounds, demonstrating that the transformation in temporal processing along the tonotopic axis contributes to efficient extraction of auditory spatial cues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.