ArticleeLife2014
Combining growth-promoting genes leads to positive epistasis in Arabidopsis thaliana.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- TCP3-mediated regulation of cell expansion in Arabidopsis thaliana.The New phytologist · 2025Article
- The PEAPOD repressor complex in Arabidopsis stomatal development.Frontiers in plant science · 2025Review
- Mining of Candidate Genes Associated with Leaf Shape Traits in Grapes.International journal of molecular sciences · 2024Article
- A dynamic ubiquitination balance of cell proliferation and endoreduplication regulators determines plant organ size.Science advances · 2024Article
- Combining multiplex gene editing and doubled haploid technology in maize.The New phytologist · 2023Article
- Higher-order epistasis shapes natural variation in germ stem cell niche activity.Nature communications · 2023Article
- BREEDIT: a multiplex genome editing strategy to improve complex quantitative traits in maize.The Plant cell · 2023Article
- Article
- A single-cell morpho-transcriptomic map of brassinosteroid action in the Arabidopsis root.Molecular plant · 2021Article
- Nocturnal gibberellin biosynthesis is carbon dependent and adjusts leaf expansion rates to variable conditions.Plant physiology · 2021Article
- Comparative Transcriptomic Analysis of the Development of Sepal Morphology in Tomato (International journal of molecular sciences · 2020Article
- Rapid Auxin-Mediated Cell Expansion.Annual review of plant biology · 2020Review
- The complex genetic architecture of shoot growth natural variation in Arabidopsis thaliana.PLoS genetics · 2019Article
- Decanalizing thinking on genetic canalization.Seminars in cell & developmental biology · 2019Review
- A Vitis vinifera basic helix-loop-helix transcription factor enhances plant cell size, vegetative biomass and reproductive yield.Plant biotechnology journal · 2018Article
- Additive Phenotypes Underlie Epistasis of Fitness Effects.Genetics · 2018Article
- From network to phenotype: the dynamic wiring of an Arabidopsis transcriptional network induced by osmotic stress.Molecular systems biology · 2017Article
- RRM domain of Arabidopsis splicing factor SF1 is important for pre-mRNA splicing of a specific set of genes.Plant cell reports · 2017Article
- Forever Young: The Role of Ubiquitin Receptor DA1 and E3 Ligase BIG BROTHER in Controlling Leaf Growth and Development.Plant physiology · 2017Article
- Natural Variation of Molecular and Morphological Gibberellin Responses.Plant physiology · 2017Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several genes positively influence final leaf size in Arabidopsis when mutated or overexpressed. The connections between these growth regulators are still poorly understood although such knowledge would further contribute to understand the processes driving leaf growth. In this study, we performed a combinatorial screen with 13 transgenic Arabidopsis lines with an increased leaf size. We found that from 61 analyzed combinations, 39% showed an additional increase in leaf size and most resulted from a positive epistasis on growth. Similar to what is found in other organisms in which such an epistasis assay was performed, only few genes were highly connected in synergistic combinations as we observed a positive epistasis in the majority of the combinations with samba, BRI1(OE) or SAUR19(OE). Furthermore, positive epistasis was found with combinations of genes with a similar mode of action, but also with genes which affect distinct processes, such as cell proliferation and cell expansion.DOI: http://dx.doi.org/10.7554/eLife.02252.001.
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