ArticleeLife2014
Atoh1-dependent rhombic lip neurons are required for temporal delay between independent respiratory oscillators in embryonic mice.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 27 citations in OpenAlex.
- AMPK Phosphorylates LMX1b to Regulate a Brainstem Neurogenic Network Important for Control of Breathing in Neonatal Mice.International journal of molecular sciences · 2024Article
- Glutamatergic cerebellar neurons differentially contribute to the acquisition of motor and social behaviors.Nature communications · 2023Article
- Machine learning-based data analytic approaches for evaluating post-natal mouse respiratory physiological evolution.Respiratory physiology & neurobiology · 2021Article
- Respiratory rhythm generation, hypoxia, and oxidative stress-Implications for development.Respiratory physiology & neurobiology · 2019Review
- The Dynamic Basis of Respiratory Rhythm Generation: One Breath at a Time.Annual review of neuroscience · 2018Review
- Loss ofeLife · 2018Article
- Phasic inhibition as a mechanism for generation of rapid respiratory rhythms.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Transcriptome of neonatal preBötzinger complex neurones in Dbx1 reporter mice.Scientific reports · 2017Article
- Molecular Mechanisms of Transcription Factor 4 in Pitt Hopkins Syndrome.Current genetic medicine reports · 2017Article
- Computational models of the neural control of breathing.Wiley interdisciplinary reviews. Systems biology and medicine · 2017Review
- Microcircuits in respiratory rhythm generation: commonalities with other rhythm generating networks and evolutionary perspectives.Current opinion in neurobiology · 2016Review
- Article
- Testing the evolutionary conservation of vocal motoneurons in vertebrates.Respiratory physiology & neurobiology · 2016Article
- Article
- Dysregulation of locus coeruleus development in congenital central hypoventilation syndrome.Acta neuropathologica · 2015Article
- State-dependent control of breathing by the retrotrapezoid nucleus.The Journal of physiology · 2015Article
- Article
- Role of parafacial nuclei in control of breathing in adult rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Facing the challenge of mammalian neural microcircuits: taking a few breaths may help.The Journal of physiology · 2015Review
- Testing the role of preBötzinger Complex somatostatin neurons in respiratory and vocal behaviors.The European journal of neuroscience · 2014Article
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7 authors at 4 institutions in 1 country.
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Abstract
All motor behaviors require precise temporal coordination of different muscle groups. Breathing, for example, involves the sequential activation of numerous muscles hypothesized to be driven by a primary respiratory oscillator, the preBötzinger Complex, and at least one other as-yet unidentified rhythmogenic population. We tested the roles of Atoh1-, Phox2b-, and Dbx1-derived neurons (three groups that have known roles in respiration) in the generation and coordination of respiratory output. We found that Dbx1-derived neurons are necessary for all respiratory behaviors, whereas independent but coupled respiratory rhythms persist from at least three different motor pools after eliminating or silencing Phox2b- or Atoh1-expressing hindbrain neurons. Without Atoh1 neurons, however, the motor pools become temporally disorganized and coupling between independent respiratory oscillators decreases. We propose Atoh1 neurons tune the sequential activation of independent oscillators essential for the fine control of different muscles during breathing.DOI: http://dx.doi.org/10.7554/eLife.02265.001.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.