Evidence map›Paper›PMID 24842907›Full record

ArticleMolecular and cellular biology2014

Recombinogenic telomeres in diploid Sorex granarius (Soricidae, Eulipotyphla) fibroblast cells.

N S Zhdanova, I Draskovic, J M Minina, T V Karamysheva, C L Novo, W-Y Liu, R M Porreca, A Gibaud, M E Zvereva, D A Skvortsov and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

N S ZhdanovaInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia zhdanova@bionet.nsc.ru Arturo.Londono@curie.fr.
I DraskovicTelomere & Cancer Laboratory, Equipe Labelisée Ligue Nationale contre le Cancer, Institut Curie, Paris, and UPMC University Paris, Paris, France.
J M MininaInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
T V KaramyshevaInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
C L NovoTelomere & Cancer Laboratory, Equipe Labelisée Ligue Nationale contre le Cancer, Institut Curie, Paris, and UPMC University Paris, Paris, France.
W-Y LiuTelomere & Cancer Laboratory, Equipe Labelisée Ligue Nationale contre le Cancer, Institut Curie, Paris, and UPMC University Paris, Paris, France.
R M PorrecaTelomere & Cancer Laboratory, Equipe Labelisée Ligue Nationale contre le Cancer, Institut Curie, Paris, and UPMC University Paris, Paris, France.
A GibaudTelomere & Cancer Laboratory, Equipe Labelisée Ligue Nationale contre le Cancer, Institut Curie, Paris, and UPMC University Paris, Paris, France.
M E ZverevaMoscow State University, Chemical Faculty, Moscow, Russia.
D A SkvortsovMoscow State University, Chemical Faculty, Moscow, Russia.
N B RubtsovInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
A Londoño-VallejoTelomere & Cancer Laboratory, Equipe Labelisée Ligue Nationale contre le Cancer, Institut Curie, Paris, and UPMC University Paris, Paris, France zhdanova@bionet.nsc.ru Arturo.Londono@curie.fr.
Institute of Cytology and Genetics · RUInstitut Curie · FRLa Ligue Contre le Cancer · FRLomonosov Moscow State University · RUSorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The telomere structure in the Iberian shrew Sorex granarius is characterized by unique, striking features, with short arms of acrocentric chromosomes carrying extremely long telomeres (up to 300 kb) with interspersed ribosomal DNA (rDNA) repeat blocks. In this work, we investigated the telomere physiology of S. granarius fibroblast cells and found that telomere repeats are transcribed on both strands and that there is no telomere-dependent senescence mechanism. Although telomerase activity is detectable throughout cell culture and appears to act on both short and long telomeres, we also discovered that signatures of a recombinogenic activity are omnipresent, including telomere-sister chromatid exchanges, formation of alternative lengthening of telomeres (ALT)-associated PML-like bodies, production of telomere circles, and a high frequency of telomeres carrying marks of a DNA damage response. Our results suggest that recombination participates in the maintenance of the very long telomeres in normal S. granarius fibroblasts. We discuss the possible interplay between the interspersed telomere and rDNA repeats in the stabilization of the very long telomeres in this organism.

Indexed as

AnimalsCells, CulturedChromosomes, MammalianDiploidyDNA, RibosomalFibroblastsRecombination, GeneticShrewsTelomeraseTelomereTelomere HomeostasisDNA, RibosomalTelomerase

Identifiers

PMID24842907
PMCPMC4135569
OpenAlexW2150573591

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.