Evidence map›Paper›PMID 24842892›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2014

Activity of P-Glycoprotein, a β-Amyloid Transporter at the Blood-Brain Barrier, Is Compromised in Patients with Mild Alzheimer Disease.

Anand K Deo, Soo Borson, Jeanne M Link, Karen Domino, Janet F Eary, Ban Ke, Todd L Richards, David A Mankoff, Satoshi Minoshima, Finbarr O'Sullivan and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 1 synthesis or guideline pooled it, 188 citations in OpenAlex.

  1. Pooled it
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  7. Article
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  10. The blood-brain barrier: a help and a hindrance.Brain : a journal of neurology · 2025
    Review
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Anand K DeoDepartment of Pharmaceutics, University of Washington, Seattle, Washington.
Soo BorsonDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington.
Jeanne M LinkDepartment of Radiology, University of Washington, Seattle, Washington.
Karen DominoDepartment of Anesthesiology, University of Washington, Seattle, Washington; and.
Janet F EaryDepartment of Radiology, University of Washington, Seattle, Washington.
Ban KeDepartment of Pharmaceutics, University of Washington, Seattle, Washington.
Todd L RichardsDepartment of Radiology, University of Washington, Seattle, Washington.
David A MankoffDepartment of Radiology, University of Washington, Seattle, Washington.
Satoshi MinoshimaDepartment of Radiology, University of Washington, Seattle, Washington.
Finbarr O'SullivanDepartment of Radiology, University of Washington, Seattle, Washington Department of Statistics, University College Cork, Cork, Ireland.
Sara EyalDepartment of Pharmaceutics, University of Washington, Seattle, Washington.
Peng HsiaoDepartment of Pharmaceutics, University of Washington, Seattle, Washington.
Ken MaravillaDepartment of Radiology, University of Washington, Seattle, Washington.
Jashvant D UnadkatDepartment of Pharmaceutics, University of Washington, Seattle, Washington jash@u.washington.edu.
University of Washington · US

Funding

Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
Institute for Translational Health Science (TL1)TL1RR025016 · NCRR · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2007 to 2011
$2.7M
Institute of Translational Health SciencesTL1TR000422 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$2.1M
P-glycoprotein and Alzheimer's DiseaseR33AG031485 · NIA · UNIVERSITY OF WASHINGTON · PI UNADKAT, JASHVANT D · 2008 to 2010
$950k
NCATS NIH HHS TL1 TR000422NCATS NIH HHS UL1 TR002319NCRR NIH HHS TL1 RR 025016NCRR NIH HHS TL1 RR025016NIA NIH HHS AG 031485NIA NIH HHS R33 AG031485
6 · The paper itself

Abstract

unlabelledStudies in animals and postmortem human brain tissue support a role for P-glycoprotein in clearance of cerebral β-amyloid across the blood-brain barrier (BBB). We tested the hypothesis that BBB P-glycoprotein activity is diminished in Alzheimer disease (AD) by accounting for an AD-related reduction in regional cerebral blood flow (rCBF).

methodsWe compared P-glycoprotein activity in mild-AD patients (n = 9) and cognitively normal, age-matched controls (n = 9) using PET with a labeled P-glycoprotein substrate, (11)C-verapamil, and (15)O-water to measure rCBF. BBB P-glycoprotein activity was expressed as the (11)C-verapamil radioactivity extraction ratio ((11)C-verapamil brain distributional clearance, K1/rCBF).

resultsCompared with controls, BBB P-glycoprotein activity was significantly lower in the parietotemporal, frontal, and posterior cingulate cortices and hippocampus of mild AD subjects.

conclusionBBB P-glycoprotein activity in brain regions affected by AD is reduced and is independent of rCBF. This study improves on prior work by eliminating the confounding effect that reduced rCBF has on assessment of BBB P-glycoprotein activity and suggests that impaired P-glycoprotein activity may contribute to cerebral β-amyloid accumulation in AD. P-glycoprotein induction or activation to increase cerebral β-amyloid clearance could constitute a novel preventive or therapeutic strategy for AD.

Indexed as

AdultAgedAlzheimer DiseaseAmyloid beta-PeptidesATP Binding Cassette Transporter, Subfamily B, Member 1Blood-Brain BarrierCarbon RadioisotopesCase-Control StudiesCerebrovascular CirculationFemaleHumansMaleMiddle AgedOxygen RadioisotopesPositron-Emission TomographyVerapamilAmyloid beta-PeptidesATP Binding Cassette Transporter, Subfamily B, Member 1Carbon RadioisotopesOxygen RadioisotopesVerapamilWaterAlzheimer’s diseaseblood–brain barrierPET imagingP-glycoprotein activityrelative extraction ratio

Identifiers

PMID24842892
PMCPMC4691246
OpenAlexW2130945756

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.